292株鲍氏不动杆菌感染的分布特征及耐药性分析  

Clinical distribution of 292 strains of acinetobacter baumannii and drug resistance

作　　者：李慧[1] 王宏伟[1] 贾红岩[1] 孙美玲[1] 王丽华[1] 

机构地区：[1]青岛大学医学院附属医院检验科,山东青岛266003

出　　处：《中华医院感染学杂志》2011年第13期2818-2819,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解临床标本中鲍氏不动杆菌的分布特征及耐药率。方法回顾性分析医院2009年7月1日-2010年6月30日鲍氏不动杆菌感染分布及耐药性。结果 292株鲍氏不动杆菌主要来源于痰液,占82.6%;分布主要以综合ICU最多,占32.9%,其次是神经外科、呼吸内科和神经内科,分别占19.2%、16.1%、6.1%;该菌对多黏菌素E的敏感率最高,为99.3%,其次头孢哌酮/舒巴坦和亚胺培南,敏感率分别为74.0%、68.2%;对其他抗菌药物耐药率约50.0%;泛耐药鲍氏不动杆菌的检出率高达30.1%。结论鲍氏不动杆菌是医院感染重要的条件致病菌,其对抗菌药物耐药率高,且易出现多药耐药或泛耐药;及时送检标本进行微生物学检测并根据药敏结果选择抗菌药物,能有效控制其引起的感染。OBJECTIVE To understand the distribution characteristics and drug resistance of Acinetobacter bauman nii in clinical specimens. METHODS Totally 292 strains of A. baumannii from patients from Jul 1st 2009 and Jun 30th, 2010 were analyzed to calculate the ratio of sample source, patient unit origin and drug sensitivity as well as Pan-drug resistant A. baumannii. RESULTS A. baumannii isolated from ICU （Intensive Care Unit）, neurosurgery department, respiratory department, and neurology department accounted for 74. 3% of whole hospital and mostly originated from sputum（82.6% ）of all A. baumannii samples. 99.3 % of them were susceptible to Polymyxin E, 74. 0% of them susceptible to Cefoperazone/sulbactam and 68.2 % susceptible to Imipenem. But the resistance rate of other antibiotics was about 50%. The ratio of Pan-drug resistant A. baumannii was as high as 30. 1%. CONCLUSION A. baumannii strains are the predominant opportunistic pathogenic bacteria in nosocomial infection, which are highly resistant and multidrug-resistant to antibiotics. Early antimicrobial agents susceptibility test is helpful to prevent and control A. bauznannii nosoeomial infection.

关 键 词：鲍氏不动杆菌 耐药性 泛耐药 

分 类 号：R378[医药卫生—病原生物学]