耐甲氧西林葡萄球菌感染的相关因素分析  

Correlative factors of methicillin-resistant staphylococcus infection

作　　者：黄琴香[1] 吴旭丽[1] 李毓芹[1] 

机构地区：[1]温州医学院附属温岭医院质控科,浙江温岭317500

出　　处：《中华医院感染学杂志》2011年第13期2830-2832,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解住院患者耐甲氧西林葡萄球菌(MRS)的感染现状及相关因素,以便采取有效的预防措施。方法采用回顾性调查方法,对2009年1-12月住院患者的各类标本中分离的385份葡萄球菌属感染病历,逐份查阅相关资料并对危险因素进行分析。结果 MRS的检出率为66.49%,耐甲氧西林金黄色葡萄球菌(MRSA)检出率为53.70%,耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检出率为75.78%;科室分布前3位的分别是重症监护病房(ICU)、神经内科和神经外科;标本主要分布在痰液和血液;感染与年龄、住院时间、入住ICU、联合使用抗菌药物、糖皮质激素、免疫抑制剂使用及侵入性操作有关(P<0.01)。结论尽量缩短住院时间、减少侵入性操作、合理使用抗菌药物、尽可能避免入住ICU以减少MRS感染的发生。OBJECTIVE To understand the infection status and related factors of Methicillin-resistant Staphylococcus （MRS） about patients, and in order to take effective preventive measures. METHODS A retrospective analysis was taken on correlative factors of hospitalized cases with Methicillin-resistant Staphylococcus （MRS） infection by analyzing 385 samples isolated from all kinds of specimens of cases with MRS infection from Jan 2009 to Dec 2009. RESULTS The detection rate of MRS was 66. 49%, Methicillin-resistant Staphylococcus aureus （MRSA） was 53. 70%, and Methicillin-resistant coagulase negative Staphylococcus （MRCNS） was 75. 78%, respectively; Distribution of top 3 departments were intensive care unit （ICU）, departments of neurology and neurosurgery, and specimens were mainly distributed in the sputum and blood. The correlative factors are age, hospitalization time, stay ICU, the joint use of antibiotics, corticosteroids, immunosuppressive agents and invasive procedures （P〈0. 01）. CONCLUSION It is necessary to shorten the length of hospitalization time, to decrease invasive procedures, rationally use the antibiotics, to decrease ICU stay as far as possible in order to reduce the incidence of MRS infection.

关 键 词：葡萄球菌属 甲氧西林 耐药性 相关因素 

分 类 号：R378.11[医药卫生—病原生物学]