leptin、CRP与CEA对癌性胸腔积液的诊断价值  

The value of leptin,CRP and CEA in the diagnosis of malignant pleural effusions

作　　者：何军[1] 朱述阳[1] 陈亮[1] 

机构地区：[1]徐州医学院附属医院呼吸内科,江苏徐州221002

出　　处：《中国现代医学杂志》2011年第16期1914-1917,共4页China Journal of Modern Medicine

摘　　要：目的探讨瘦素(leptin)、C-反应蛋白(CRP)和癌胚抗原(CEA)对癌性胸腔积液诊断的临床意义。方法良性和癌性胸腔积液患者的胸水和血清标本中的leptin含量采用双抗体夹心酶联免疫吸附法(ELISA)、CRP采用免疫比浊法和CEA含量放射免疫分析法(RIA)来测定。结果恶性组胸水和血清的leptin含量([38.29±18.22)ng/L和(19.49±13.27)ng/L]高于良性组([25.24±23.69)ng/L和(10.73±11.56)ng/L];恶性组胸水和血清的CRP含量([16.31±13.79)mg/L和(40.76±26.15)mg/L]低于良性组([28.59±15.61)mg/L和(61.54±31.96)mg/L];恶性组胸水和血清的CEA含量([76.40±136.32)ng/mL和(22.72±48.04)ng/mL]明显高于良性组([5.35±11.95)ng/mL和(2.88±4.59)ng/mL],差异均有显著性;胸水中联合检测leptin和CEA对癌性胸腔积液的诊断价值最高,其敏感性和特异性分别为53%和97%。结论癌性胸腔积液患者的血清与胸水中的leptin、CRP和CEA浓度对诊断癌性胸腔积液有临床价值,其中以胸水中联合检测leptin和CEA对癌性胸腔积液的诊断价值最高。[Objective] To explore differential diagnosis value of leptin,C-reactive protein and CEA for malignant pleural effusions.[Methods] The concentrations of leptin in the serum and pleural effusions were measured by enzyme-linked immunosorbent assay（ELISA） in the malignant and benign pleural effusion patients,and C-reactive protein were by Immunodiffusion and CEA were by RIA.[Results] The concentrations of leptin in the pleural fluids and serum of malignant pleural effusions were higher than benign pleural effusions [（38.29±18.22） ng/L （19.49±13.27） ng/L VS（25.24±23.69） ng/L （10.73±11.56） ng/L];The CRP levels in the pleural effusions and serum of malignant pleural effusions were less than that in benigns [（16.31±13.79） mg/L （40.76±26.15） mg/L VS（28.59±15.61） mg/L （61.54±31.96） mg/L];The concentrations of CEA in the pleural fluids and serum of malignant pleural effusions were higher than benign pleural effusions [（70.64±136.32） ng/L （22.72±48.04） ng/L VS（5.35±11.95） ng/L （2.88±4.59） ng/L];The highest diagnosis value of malignant pleural effusions was combined measurement of leptin and CEA in pleural effusions,and the sensitivity and specificity were 53% 97%.[Conclusion] Leptin,CRP and CEA are useful parameters for differential diagnosis of malignant pleural effusions,the highest diagnosis value of malignant pleural effusions is combined measure of leptin and CEA in pleural effusion.

关 键 词：癌性胸腔积液 瘦素 C-反应蛋白 癌胚抗原 诊断 

分 类 号：R561.3[医药卫生—呼吸系统]