2006年至2009年我院铜绿假单胞菌的临床分布及耐药性分析  

Clinical distribution and drug resistance analysis of pseudomonas aeruginosa in our hospital from 2006 to 2009

作　　者：赵方[1] 张志宏[1] 赵丽香[1] 

机构地区：[1]山东省千佛山医院感染管理科,济南250014

出　　处：《中国实用医刊》2011年第14期47-49,共3页Chinese Journal of Practical Medicine

摘　　要：目的调查铜绿假单胞菌（PA）在千佛山医院院内感染的临床分布及其耐药情况，以便指导临床合理应用抗菌药物。方法采集本院2006年6月至2009年12月我院确诊的368例铜绿假单胞菌院内感染患者的各类标本，分离出铜绿假单胞菌，采用K—B纸片琼脂扩散法进行药敏试验。结果铜绿假单胞茵以痰标本中分离最高，占65．8％，铜绿假单胞菌感染主要发生于重症监护病房（占52．7％）；其中亚胺培南、哌拉西林／他唑巴坦、头孢哌酮／舒巴坦、阿米卡星对铜绿假单胞菌较敏感，耐药率依次是15．6％、17．8％、22．8％、25．6％；头孢曲松、氨苄西林、氨苄西林／舒巴坦、头孢唑林、复方新诺明和呋喃妥因高度耐药。结论铜绿假单胞菌对常用的抗生素耐药率较高，临床应严格遵守抗生素使用原则，合理应用抗生素。Objective To learn the sample distribution of hospital infection and drug resistance of pseudomonas aeruginosa, to guide rational drug use in clinic. Methods We retrospectively investigated 368 cases of pseudomonas aeruginosa infection in our hospital from 2006 to 2009. Drug sensitivity test was carried out by NCCLS KB disc method recommended by WHO. Results The infection of pseudomonas aeruginosa was isolated mainly from sputum 65.8 % and 52.7% of P. aeruginosa infection occurred in ICU. Imipenem, piperacillin/tazobactam, cefoperazone/sulbactam and amikacin were sensitive in P. aeruginosa. Antibiotic resistance to ampicillin, cefazolin, ampicillin/ sulbactam nit rofurantoin and SMZ - TMP were 15.6% , 17.8%, 22.8% , 25.6%. Conclusions The resistance rate of pseudomonas aeruginosa of common antibiotics is high. We should abide strictly by the rules of antibiotics using and use antibiotics rationally.

关 键 词：铜绿假单胞菌 医院内感染 临床分布 耐药性 

分 类 号：R446.5[医药卫生—诊断学]