慢性阻塞性肺疾病患者去脂体重与最高运动状态反应的相关性  

Peak exercise response in relation to fat-free mass in patients with chronic obstructive pulmonary disease

作　　者：周锋[1] 刘锦铭[1] 杨文兰[1] 孙兴国[2] 

机构地区：[1]同济大学附属上海市肺科医院呼吸科,200433 [2]90502美国加州大学洛杉矶分校Harbor-UCLA医学中心洛杉矶生物医学研究院圣约翰心血管研究中心

出　　处：《国际呼吸杂志》2011年第13期968-972,共5页International Journal of Respiration

摘　　要：目的探讨去脂体重（FFM）与慢性阻塞性肺疾病（COPD）患者最高运动状态反应的相关性。方法26例正常对照组和62例稳定期COPD患者进行负荷连续递增的运动心肺功能试验。其中稳定期COPD患者按照第1秒用力呼气容积占预计值百分比（FEV，％pred）分成轻度、中度和重度，在运动中检测受试者最高运动状态时氧耗量（peakVO2）、最高运动状态时运动负简（peakLoad）、最高运动状态时氧脉搏（peakO2pulse）、无氧阈（AT）等各项参数。运动前进行FFM测定和常规肺功能检杏。结果①重度COPD患者FFM明显低于对照组，差异有统计学意义（P〈0．05）；②重度COPD组的peakVO2、peakVO2Koopred、peakLoad、peakLoad％pred、peakO2pulse、peakO2pulse%pred和AT均显著低于对照组，差异有统计学意义（P〈0．05）；③FFM与peakVO2％pred、peakLoad％pred、AT和peakO2pulse％pred呈正相关（r=0．671，0．478，0．423，0．618，P值均〈0．05）。结论FFM与COPD患者肌肉代谢和运动耐力相关。Objective To explore the relationship between fat-free mass （FFM） and peak exercise performance in chronic obstructive pulmonary disease（COPI））patients. Methods 26 healthy suhjects and 62 stable COPD patients performed incremental cardiopulmonary exercise testing with cycle ergometer. 62 stable COPD patients were divided three groups（mild COPD,moderate COPD,severe COPD） according to FEV1% pred, peakVO2 , peakLoad, peakO2 pulse, AT were measured during exercise. FFM and routine pulmonary function tests were performed in all subjects before testing. Results （1） Compared with the healthy subjects, the severe COPD patients were lower in FFM（ P 〈0.05）. （2）Compared with the heahhy subjects, peakVO2 , peakVO2 % pred, peakLoad, peakLoad % pred, peakO2 pulse, peakO2 pulse% pred and AT showed the greater decline in severe COPD. （3）FFM was positively correlated with peakVO2 % pred, peakLoad% pred,AT and peakO2 pulse%pred （ r =0. 671,0. 478,0. 423,0. 618, P 〈0.05） in COPD patients. Conclusions FFM is significantly associated with muscle aerobic capacity and exercise tolerance in COPD patients.

关 键 词：去脂体重 慢性阻塞性肺疾病 心肺运动试验 

分 类 号：R563.9[医药卫生—呼吸系统]