人芽囊原虫病患者肠黏膜表皮生长因子水平及其临床意义  

Intestinal mucosa of epidermal growth factor in patients with Blastocystis hominis infection and its clinical significance

作　　者：俞开敏[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《中国病原生物学杂志》2011年第6期437-439,共3页Journal of Pathogen Biology

摘　　要：目的检测人芽囊原虫感染者肠黏膜表皮生长因子(EGF)的水平,探讨EGF与肠黏膜损伤程度的关系。方法感染组为确诊人芽囊原虫感染者44例,对照组为健康体检者40例,均经电子肠镜检查肠黏膜病变情况,并用ELISA法检测肠黏膜组织匀浆EGF水平。结果电子肠镜检查可见人芽囊原虫感染者的肠黏膜有不同程度病变,表现为充血、水肿、糜烂、溃疡等。感染组EGF为(559.60±178.5)pg/ml,对照组为(977.58±215.5)pg/ml,差异有统计学意义(t=9.7136,P<0.01)。且EGF水平随着肠黏膜病变严重程度的增加而逐渐降低。结论人芽囊原虫感染能引起患者肠黏膜的病理改变及肠黏膜EGF水平降低。人芽囊原虫感染所致肠黏膜损伤可能与原虫的侵入及黏膜中EGF的减少有关。EGF在人芽囊原虫病肠道损伤的修复中起重要作用。Objective To detect epidermal growth factor （EGF） in intestinal mucosa in patients with Blastocystis hominis infection and explore the relationship between EGF and intestinal mucosa lesions. Methods Forty- four patients who were diagnosed with B. hominis infection served as the infected group and 40 healthy persons served as the control group. Endoscopy and intestinal biopsy were performed to observe pathological changes in the intestine. The patients＇and the controls＇intestinal tissue homogenate were tested for EGF with ELISA assays. Results Intestinal mucosa lesions were observed in all patients infected with B. hominis. Pathological manifestations included mucosal congestion, edema, erosion, and ulceration. The level of EGF in the infected group was （559.60±178.5） pg/ml, and that in the control was （977.58±215.5） pg/ml. The difference between the two was significant （t=9. 7136,P〈0.01）. Furthermore, the level of EGF gradually decreased with the severity of intestinal mucosa lesions. Conclusion B. hominis infection can cause intestinal mucosa lesions and reduce levels of EGF in the intestinal mucosa. The intestinal mucosa lesions caused by B. hominis infection may correlate with parasite invasion and reduced levels of EGF, and EGF plays an important role in the repair of intestinal mucosa lesions.

关 键 词：人芽囊原虫 肠黏膜 损伤 表皮生长因子 

分 类 号：R382.5[医药卫生—医学寄生虫学]