柔毛淫羊藿对骨质疏松小鼠的作用研究  

Effects of Epimedium pubescens Maxim.on osteoporosis in ovariectomized mouse

作　　者：韩小东[1] 张金娟[2] 任光友[2] 张贵林[2] 

机构地区：[1]延安大学医学院临床系,陕西延安716000 [2]贵阳医学院药理教研室,贵州贵阳550004

出　　处：《中国医药导报》2011年第19期55-56,共2页China Medical Herald

摘　　要：目的:探讨柔毛淫羊藿对骨质疏松小鼠骨密度、破骨细胞和IL-6的作用。方法:采用切除雌性小鼠双侧卵巢复制骨质疏松整体动物模型,按小鼠体重随机分对照组(蒸馏水10 ml/kg)、模型组(蒸馏水10 ml/kg)、DES组(2 mg/kg)、EPM高剂量组(200 mg/kg)、EPM中剂量组(100 mg/kg)、EPM低剂量组(50 mg/kg),每组14只。无钙饲料喂养,自然饮水。分别按各组相应药物相应剂量灌胃给药,60 d后测小鼠骨密度、破骨细胞数和IL-6含量。结果:模型组动物呈现明显的骨质疏松表现;给药组动物骨密度增加、破骨细胞数和IL-6表达明显降低,且有统计学意义。结论:柔毛淫羊藿能够增加去卵巢骨质疏松症小鼠的骨密度、降低破骨细胞数和IL-6的表达。Objective：To explore the effect of EPM on osteoporosis in ovariectomized mouse.Methods：An ovariectomized mouse model was established.These mice were divided into six groups：control group,model group,diethylstilbestrol positive control group,high dose of EPM group,middle dose of EPM group and low dose of EPM group.Each group of 14.60 days after,bone density,the osteoclast and IL-6 of the bone tissue was measured.Results：The model group animals had the obvious performance of osteoporosis;bone density increased,the osteoclast number and IL-6 were decreasing obviously.Conclusion：EPM can increase the density.EPM has an apparent role of anti-osteoporosis in ovariectomized mice.And its mechanism may be related to the reducing of the osteoclast number and the level of IL-6.

关 键 词：柔毛淫羊藿 骨质疏松 IL-6 骨密度 

分 类 号：R965[医药卫生—药理学]