生长抑素联合泮托拉唑治疗肝硬化上消化道大出血的疗效观察  

Clinical observation of Somatostation combined Pantoprazole in the treatment of liver cirrhosis with upper gastrointestinal massive hemorrhage

作　　者：杜建新 蒋锦华[2] 李樱 芦红 

机构地区：[1]河南省平顶山市第二人民医院,河南平顶山467000 [2]河南省平顶山市疾病预防控制中心,河南平顶山467000

出　　处：《中国医药导报》2011年第19期143-144,共2页China Medical Herald

摘　　要：目的:观察生长抑素联合泮托拉唑在治疗肝硬化并发上消化道大出血止血治疗中的疗效。方法:随机将136例患者分为治疗组(n=68)和对照组(n=68),治疗组应用生长抑素联合泮托拉唑治疗,先应用生长抑素250μg静脉推注,然后以250μg/h的速度持续微量泵滴入,维持48～72 h;泮托拉唑40mg加入生理盐水100 ml中静脉滴注,2次/d,维持48～72 h。对照组单用生长抑素治疗,先生长抑素250μg静脉推注,然后250μg/h持续微量泵注射,维持48～72 h,观察各组治疗效果。结果:治疗组治疗总有效率为97.06%,高于对照组的85.30%,差异有统计学意义(P<0.05)。结论:生长抑素联合泮托拉唑是治疗肝硬化上消化道大出血的有效措施之一,疗效优于单用生长抑素的止血效果,且副作用小,值得临床推广,更适合基层医院临床应用。Objective：To observe the efficacy of Somatostation combined Pantoprazole in the treatment of liver cirrhosis with upper gastrointestinal massive hemorrhage.Methods：136 patients were divided into the treatment group（n=68） and the control group（n=68）.The treatment group was treated with Somatostation and Pantoprazole,first intravenous bolus injection of Somatostation 250 μg/h,then by 250 μg/h with the micro-pump to drip into,maintains 48-72 h,Pantoprazole（40 mg） were added to 100 ml NS,with intravenous drip,2 times/d.The control group was treated with Somatostation,first intravenous bolus injection of Somatostation 250 μg/h,then by 250 μg/h with the micro-pump to drip into,maintains 48-72 h.The treatment results in the two groups were observed.Results：The total effective rate of the treatment group was 97.06%,which was higher than the control group of 85.30%,there was a significant difference（P0.05）.Conclusion：Combination of Somatostation and Pantoprazole is one of the effective actions to treat the upper gastrointestinal massive hemorrhage,the efficacy of hemostatic is better than using Somatostation alone,and the side reaction is small,which is worthy of being recommended in clinical promotion and more suitable for basic unit hospital.

关 键 词：生长抑素 泮托拉唑 肝硬化 上消化道大出血 

分 类 号：R657.3[医药卫生—外科学]