芪丹化痰汤对急性心肌缺血大鼠损伤保护作用研究  

Protective Efect of Qi-dan-hua-tan Decoction on Acute Myocardial Ischemia Injury of Rat

作　　者：姜岑[1] 谢磊[1] 王卫星[2] 黄秀深[1] 贾波[1] 

机构地区：[1]成都中医药大学基础医学院,四川成都618041 [2]四川省中医院,四川成都610075

出　　处：《成都中医药大学学报》2011年第2期49-51,共3页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：成都中医药大学科技发展基金项目(编号:ZRYB200926)

摘　　要：目的:观察芪丹化痰汤对急性心肌缺血损伤的保护作用。方法:60只Wistar大鼠随机分为空白组、模型组、芪丹化痰汤高、中、低剂量组和马来酸依那普利组,空白组与模型组给予生理盐水;芪丹化痰汤高、中、低剂量组和西药组给予连续灌药7 d。灌药第7 d,除空白组外,其余组给予垂体后叶素(0.6 U/kg)腹腔注射造模。1 h后腹主动脉取血检测血清肌酸激酶(CK)、乳酸脱氢酶(LDH)表达水平。结果:与空白组比较,模型组血清中LDH、CK含量显著升高(P<0.05);与模型组比较,各治疗组可降低血清中CK、LDH的活性及含量(P<0.05或P<0.01);各治疗组之间比较,无统计学差异(P>0.05)。结论:芪丹化痰汤可通过降低急性心肌缺血中血清CK、LDH的活性及含量,有效保护缺血心肌。Objective： To observate the protection of the Qidanhuatan Decoction on acute myocardial ischemia injury.Methods： 60 Wistar rats were divided randomly into the blank group,the model group,the Qidanhuatantang with low dose group、the Qidanhuatantang with normal dose group and the Qidanhuatantang with high dose group,enalapril maleatet group,10 rats per group.The blank group and the model group were given saline water,while all treatment groups were given medicines,continuing 7 days.After 7 day for perfuse drug,except the blank group,the others groups were given hypophysin（0.6U/kg）intraperitoneal injection for modeling.The expression level of Serum CK,LDK were measured after 1 hours through draw blood from abdominal aorta.Results： Comparison with blank group,the level of serum level of CK,LDK in model group was obviously higher（P0.05）;comparison with model group,all treatment groups decreased serum activity and content of CK,LDK（P0.05）,there was no significantly difference between treatment groups.Conclusion： The Qidanhuatan Decoction could decreas the serum activity and content of CK,LDK of acute myocardial ischemia,which could effectively protectischemic myocardium.

关 键 词：心肌缺血 芪丹化痰汤 血清肌酸激酶 乳酸脱氢酶 

分 类 号：R285.5[医药卫生—中药学]