血浆置换对大疱性类天疱疮患者皮损糖皮质激素受体α和β表达影响的研究  

EFFECT OF PLASMA EXCHANGE ON THE EXPRESSION OF GRα AND GRβ IN THE LESION OF BULLOUS PEMPHIGOID

作　　者：杜明[1] 张秀娟[1] 

机构地区：[1]河北工程大学附属医院皮肤科,河北邯郸056002

出　　处：《河北医科大学学报》2011年第5期545-546,共2页Journal of Hebei Medical University

摘　　要：目的了解血浆置换对大疱性类天疱疮(激素治疗抵抗)患者皮损糖皮质激素受体(glucocorticoid receptor,GR)α和β表达的影响,探讨血浆置换在临床治疗的意义。方法选择33例临床诊断为大疱性类天疱疮(激素治疗抵抗)患者在血浆置换前后的皮损。用免疫组织化学SP法(链酶卵白素-过氧化物酶法)检测血浆置换前后患者皮损中GR-α、GR-β的表达强度和分布特点。结果血浆置换前后的表皮各层细胞中GR阳性细胞表达强度不同(P<0.05)。结论血浆置换与皮损组织中的GR表达强度具有相关性,可为临床治疗提供理论依据。Objective In order to understand the role and significance of the glucocorticoid receptor （GR） expressions in bullous pemphigoid （glueocorticoid resistant patients） skin lesions after plasma exchange, we investigated the expressions of GRα and GRβ with immunohistochemistry method in the skin before and after plasma exchange. Methods Thrity - three glucocorticoid resistant patients with bullous pemphigoid were enrolled into this study. The skin were taken from the same part of the patients before and after plasma exchange. The expression of GRα and GRβ was detected by immunohistochemical SP method. Results The intensity of the GR expression in the patients before and after plasma exchange was different （P 〈 0.05）. Conclusion Plasma exchange has a correlation with the expression of GR in skin lesions,which can provide theoretical basis for clinical treatment of bullous pemphigoid.

关 键 词：血浆置换 类天疱疮 大疱性 受体 糖皮质激素 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]