酒石酸美托洛尔片含量测定方法的改进  

Improvement of Assay for Metoprolol Tartrate Tablets

作　　者：王震红[1] 杨永刚[1] 张伏[1] 张璐[1] 

机构地区：[1]辽宁省食品药品检验所,沈阳110023

出　　处：《中国药品标准》2011年第3期209-210,共2页Drug Standards of China

摘　　要：目的:建立酒石酸美托洛尔片中酒石酸美托洛尔的含量测定方法。方法:采用HPLC法测定,色谱柱为Diamonsil C18柱;流动相为醋酸铵缓冲液(3.9 g醋酸铵,加水至810 mL,加三乙胺2.0 mL,加冰醋酸10 mL,加磷酸3.0 mL)-乙腈(75∶25),流速1.0 mL.min-1;检测波长275 nm。结果:酒石酸美托洛尔线性范围为0.989 6～8.906 4μg;平均回收率为100.02%(n=9),RSD为0.76%。结论:本方法简便、快速,专属性强,可有效的控制酒石酸美托洛尔片中酒石酸美托洛尔的含量。Obiective： To establish a method for the determination of Metoprolol Tartrate in Metoprolol Tartrate Tablets. Methods： The HPLC column was Diamonsil C18 column. The mobile phase was Ammonium Acetate buffer solution（ Dissolve 3.9 g of ammonium acetate in water to make 810 mL, add 2.0 mL of triethytamine 10 mL of and acetic acid glacial, 3.0 mL of phosphoric acid-acetonitrile （75： 25） ;with flow rate 1.0 mL · min^-1 . The UV detection wavelength was 275 nm. Results： The linear range was 0. 989 6-8. 906 4 μg. The average recovery rate（ n = 9） was 100. 02% （ RSD 0.76% ）. Conclusion： The method was convenient, accurate, simple and feasible. It can be used as a method of quality control.

关 键 词：酒石酸美托洛尔片 高效液相色谱法 含量测定 

分 类 号：R921.2[医药卫生—药学]