咳喘合剂对COPD模型大鼠肺组织中IL-8、CC16表达的影响  

Effects of cough mixture on expression of IL-8、CC16 in lung tissue of rat modle with COPD

作　　者：王保健[1] 程艳慧[1] 何东初[2] 

机构地区：[1]解放军153医院呼吸内科,河南郑州450042 [2]广州军区武汉总医院综合科,湖北武汉430070

出　　处：《中国误诊学杂志》2011年第19期4553-4555,共3页Chinese Journal of Misdiagnostics

摘　　要：目的通过检测慢性阻塞性肺疾病(COPD)大鼠肺组织IL-8、CC16的水平变化,探讨咳喘合剂的疗效及气道修复作用。方法通过烟熏和气道内滴注脂多糖复制COPD大鼠模型,观察正常组、模型组、低剂量组、中剂量组、高剂量组IL-8、CC16在肺组织的表达。结果与正常组相比,COPD模型组大鼠肺组织IL-8显著上升,CC16浓度下降(P<0.05);经治疗后治疗组与模型组相比IL-8表达减少,CC16表达增加(P<0.05)。结论咳喘合剂有抗炎及保护气道黏膜作用。Objective To explore the efficacy and the air repaired effect of Cough Mixture by detecting the change of IL-8,CC16 levels of lung tissue of rat modle with COPD.Methods The rat model of COPD was established by smoking and copying with airway instillation of lipopolysaccharide to observe IL-8,CC16 in the lung tissues in the normal group,model group,low dose group,middle dose group and high dose group.Results Compared with normal group,IL-8 of lung tiss in COPD model group increased significantly,but CC16 levels decreased（P0.05）;the groups after treatment compared with the model group,the IL 8 was decreased,but CC16 was increased（P0.05）.Conclusion Cough Mixture can an antiinflammatory and protective role in airway mucosa.

关 键 词：止咳化痰平喘剂/药理学/治疗应用 肺疾病 慢性阻塞性/药物疗法 白细胞介素8/代谢 子宫珠蛋白/代谢 疾病模型 动物 

分 类 号：R563[医药卫生—呼吸系统]