μ阿片样受体A118G基因多态性对男性手术患者电刺激痛觉敏感性的影响  

Effects of A118G polymorphism in μ opioid receptor gene on pain sehsitivity to electric stimulation in male patients undergoing operation

作　　者：张卫[1] 张豪勇[1] 阚全程[2] 常琰子[1] 王中玉[1] 袁静静[1] 储勤军[1] 

机构地区：[1]郑州大学第一附属医院麻醉科,郑州450052 [2]郑州大学第一附属医院临床药理基地河南省高等学校临床医学重点学科开放实验室,郑州450052

出　　处：《郑州大学学报（医学版）》2011年第3期449-452,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨人类μ阿片受体基因A118G(OPRM1A118G)多态性对男性手术患者电刺激痛阈和耐痛阈的影响。方法:选择择期拟行腹部手术男性患者132例,使用聚合酶链反应-限制性片段长度多态性技术检测OPRM1A118G多态性。根据基因型将患者分为野生纯合子(A/A)(n=56)、突变杂合子(A/G)(n=60)和突变纯合子(G/G)(n=16)。采用电刺激测定3组患者痛阈和耐痛阈。结果:G等位基因频率为34.8%。3种基因患者痛阈比较,差异无统计学意义(F=0.565,P=0.610)。3种基因型患者耐痛阈比较,差异有统计学意义(F=12.236,P=0.025),G/G型患者耐痛阈高于A/A型和A/G型(P<0.05);A/G型耐痛阈高于A/A组(P<0.05)。结论:OPRM1A118G等位基因突变可提高男性手术患者电刺激痛的耐痛阈。Aim：To investigate the effects of A118G polymorphism in μ opioid receptor gene on pain sensitivity to electric stimulation in male patients undergoing operation.Methods：One hundred and thirty-two male patients were divided into 3 groups according to genotype： group A/A（wild-type homozygous,n=56）,group A/G（mutant heterozygous,n=60） and group G/G（mutant homozygous,n=16）.Genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism for A118G polymorphism.Pain threshold and pain tolerance threshold were measured using electrical stimulation.Results：The G allele frequency was 34.8%.There were no differences in pain threshold among the 3 groups（F=0.565,P=0.610）.However,the pain tolerance threshold had significant differences among the 3 group （F=12.236,P=0.025）,which was significantly higher in group G/G than those in group A/A and group A/G（P0.05）.Conclusion： The A118G allele gene mutation increases pain tolerance threshold in male patients undergoing operation.

关 键 词：μ阿片样受体 单核苷酸多态性 电刺激 痛阈 耐痛阈 男性 

分 类 号：R614.1[医药卫生—麻醉学]