燃煤型砷中毒患者体内无机砷及相关因素对病情的影响  

Influence of Inorganic Arsenic on the Condition of the Patients with Arsenism Caused by Burning Coal and other Related Factors

作　　者：张爱华[1] 黄晓欣[2] 罗鹏[1] 杨大平[2] 蒋宪瑶[1] 谢亚雄[1] 蒙顺松[1] 汪希兰[1] 郭渝成[2] 张碧霞[2] 秦少先 薛发佳 曾庆堂 周代兴 

机构地区：[1]贵阳医学院预防医学系,贵阳550004 [2]解放军第44医院 [3]贵州省地方病防治办公室 [4]贵州省兴仁县卫生局 [5]贵州省兴仁县防疫站 [6]贵州省黔西南州防疫站

出　　处：《贵阳医学院学报》1999年第4期326-329,333,共5页Journal of Guiyang Medical College

基　　金：国家自然科学基金!(39660070 号);贵州省自然科学基金

摘　　要：通过分析燃煤型砷中毒病区人群尿总砷（Ｔｏｔ－ Ａｓ） 、尿无机砷（Ｉｎ － Ａｓ） 、无机砷／ 总砷比值（Ｉｎ － Ａｓ／Ｔｏｔ－ Ａｓ） 和发砷以及相关因素对病情的影响，发现患者体内砷负荷的累积性增加及机体解毒能力的逐渐下降可能是砷中毒病情逐渐加重的原因之一。病区居民长期燃用高砷煤致空气、食品严重污染以及改灶措施不彻底，是导致新发病人不断出现、病情继续发展及皮肤癌逐渐增加的原因。研究初步揭示砷中毒患者无机砷代谢研究的必要性，并对砷中毒综合防治措施提出建议。This paper analyzed the influence on arsenism of total arsenic (Tot-As) and inorganic arsenic (In-As) in urine, the ratio of In-As to Tot-As(In-As/Tot-As), arsenic in hair and other related factors. The results showed that the increased accumulation of arsenic and the gradual decrease of detoxication in the patients might aggrevate arsenism.Severe arsenic pollution in air and food caused by burning hyperarsenic coal daily for long time, inferior improvement of stoves, poor supervision, less-developed economy and culture were the reasons for the continuous appearance of new arsenism patients, continuous deterioration of clinical manifestations of arsenism and the gradual increase of skin cancer. This paper preliminarily revealed the necessity to study In-As metabolism of the patients and made some suggestions for the comprehensive prevention and treatment of arsenism.

关 键 词：砷中毒 尿 燃煤型 头发 致癌 体内无机砷 

分 类 号：R599.9[医药卫生—内科学]