杏仁内侧核注射微量精氨加压素对原发性高血压大鼠血压、心率的影响  

Effects of Microinjection of Vasopressin into Medial Amygdaloid Nucleus on Blood Pressure and Heart Rate in Spontaneously Hypertensive Rate

作　　者：高列[1] 蒋乃昌[1] 

机构地区：[1]贵阳医学院生理教研室,贵阳550004

出　　处：《贵阳医学院学报》1999年第4期359-361,364,共4页Journal of Guiyang Medical College

摘　　要：观察电刺激及微量精氨加压素（ＡＶＰ） 注入原发性高血压大鼠（ＳＨＲ） 杏仁内侧核（ＡＭＥ） 的心血管效应。结果发现，（１） 在ＳＨＲ：电刺激（２００μＡ） ＡＭＥ 引起明显的升压效应，ＡＭＥ 内注射ＡＶＰ（３００ ｎｇ，０ ．３ μｌ ＣＳＦ） 同样引起明显的升压效应和加快心率效应；（２） 在正常大鼠（ ＷＫＹ） ：电刺激（２００μＡ） 和注射ＡＶＰ（３００ ｎｇ ，６００ ｎｇ，０ ．３μｌ ＣＳＦ） 也引起升压反应和加快心率效应，但是，该心血管反应强度明显较ＳＨＲ低，其差别有统计学意义。表明：（１）ＡＶＰ 可在ＳＨＲ 的ＡＭＥ 区域发挥对心血管活动的中枢控制作用；（２） 在接受电刺激或注射微量ＡＶＰ后，ＳＨＲ 的ＡＭＥ所表现出的对心血管活动的兴奋效应明显强于ＷＹＫ。Our studies were done to determine (1) the cardiovascular effects of electrical stimulating and microinjection of vasopressin (AVP) into the medial amygdaloid nucleus (AME) in anesthetized spontaneously hypertensive rat (SHR) and (2) whether these effects differ from between normotensive Wistar-Kyoto rat (WKY) and SHR.Electrical stimulation (200 μA) of AME in SHR elicited a pressor response. Injection of AVP (300 ng,0.3 μl CSF) into the AME of SHR also produced a marked increase in mean arterial pressure and heart rate. Both electrical stimulation (200μA) and injection of AVP (300 and 600 ng,0.3μl CSF) into AME in WKY led the rats to hypertension and tachycardia, but the aforementioned effects are not so significant as those in SHR.These results suggest that (1) AVP acts in the region of AME to exert a central action on the circulation in SHR;(2) The AME of SHR is more sensitive than that of WKY to injection of AVP and electrical stimulation influencing the cardiovascular function.

关 键 词：杏仁核 高血压 精氨升压素 血压 心率 大鼠 

分 类 号：R544.102[医药卫生—心血管疾病]