高龄老年高血压人群血尿酸浓度与脑梗死的相关性研究  

Association of serum uric acid with cerebral infarction in very elderly patients with hypertension

作　　者：常彬宾[1] 肖欣荣[1] 吕柏宁[1] 戎健[1] 胡猛[1] 

机构地区：[1]成都军区总医院干部病房第四病区,610083

出　　处：《中华保健医学杂志》2011年第3期183-185,共3页Chinese Journal of Health Care and Medicine

摘　　要：目的探讨高龄老年高血压患者血尿酸（UA）水平与脑梗死的关系。方法选取2009年在我院老年科住院的年龄≥80岁的高血压和脑梗死患者572例,根据所患疾病分为高血压组（Ⅰ组387例）和高血压合并脑梗死组（Ⅱ组185例）,测定UA、血清肌酐（Cr）、高密度脂蛋白胆固醇（HDL-C）、血糖等生化指标,分析UA水平与高血压合并脑梗死的相关性。结果Ⅰ组UA为（312.49±55.31）μmol/L、Cr为（86.48±18.38）μmol/L、HDL-C为（1.29±0.37）mmol/L;Ⅱ组UA为（397.76±63.64）μmol/L、Cr为（100.52±19.99）μmol/L、HDL-C为（1.11±0.33）mmol/L。两组比较分别为P=0.001、P=0.001、P=0.024。Logistic回归分析显示,脑梗死患病率与UA（OR1.727,95%CI1.258-3.903）和HDL-C（OR0.794,95%CI0.663-0.975）明显相关。结论 UA增高是高血压合并脑梗死的一个重要危险因素。Objective To evaluate the relation between serum UA and cerebral infarction. Methods Five hundred and seventy-two very elderly hospitalized patients with hypertension in the Department of Geriatrics were divided into two groups. Three hundred and eighty-seven patients who weren＇t diagnosed with cerebral infarction formed group I while one hundred and eighty-five patients with cerebral infarction belonged to group Ⅱ. Blood biochemical patterns and clinical medical history were compared between two groups. Results The level of serum UA in group Ⅰ is（312.49±55.31）μmol/L,the Cr is（86.48±18.38）μmol/L,and the HDL-C is（1.29±0.37）mmol/L,while the group Ⅱ is（397.76±63.64）μmol/L,（100.52±19.99）μmol/L and（1.11±0.33）mmol/L. Apparently,the level of UA,Cr and HDL-C are significantly different between the two groups. Logistic regression analysis showed that UA（OR=1.727,95%CI 1.258-3.903）was positively correlated with prevalence of cerebral infarction. Conclusions Serum UA is the risk factors of cerebral infarction.

关 键 词：高血压 脑梗死 高龄老年人 尿酸 

分 类 号：R544.1[医药卫生—心血管疾病]