小肠清除尿素和肌酐的影响因素研究  

Influence factors in the clearance of urea and creatinine through gastrointestinal tract

作　　者：黄铮 蒋云生 罗季安 

出　　处：《湖南医科大学学报》1999年第6期513-515,532,共4页Bulletin of Hunan Medical University

摘　　要：观察不同渗透浓度、pH 值及各种药物的透析液对兔小肠清除尿素、肌酐的影响。采用Terato 方法钳夹兔双肾动脉,静脉注射尿素(1-3 g·kg- 1) 、肌酐(100 mg·kg- 1) ,分别于十二指肠距幽门及回肠距回盲瓣5 cm 处造瘘,行小肠透析。结果显示:高渗甘露醇、酚妥拉明、包醛氧化淀粉均能提高肠粘膜的尿素清除率,阿托品提高肠粘膜的尿素和肌酐清除率,肠腔pH 变化对小肠的尿素。To investigate the affection of different osmotic density, pH value, and dialytic fluid with drugs on the clearance of urea and creatinine through gastrointestinal tract, we used the renal artery ligated rabbits as the model. After the intravenous administration of urea and creatinine through ear vein, fistulas in duodenum at about 5?cm to pylorus and in ileum at about 5?cm to the valva ileocecalis were made to carry out intestinal dialysis. The results showed that the clearance of the urea in treated groups with mannitol, regitine, and oxystarch was higher than that in the control group with normal saline solution(P<0.05). The clearance of urea and creatinine in treated groups with atropine was higher than that in the control group(P<0.05). There was no significant difference in the clearance of urea and creatinine among treated groups with different intestine pH value.

关 键 词：尿素 肌酐 胃肠透析 小肠 清除率 

分 类 号：R459.5[医药卫生—治疗学]