吗啡分次注射联合间苯三酚治疗肾绞痛的疗效观察  

Clinical efficacy of multiple injection of morphine combined with phloroglucin in the treatment of renal colic

作　　者：宋小兵[1] 赵剡[1] 潘正启[1] 杨奇盛[1] 王翔[1] 沈俊[1] 

机构地区：[1]武汉大学中南医院急诊科,武汉430071

出　　处：《临床急诊杂志》2011年第3期147-148,150,共3页Journal of Clinical Emergency

摘　　要：目的:评价吗啡分次注射联合间苯三酚治疗肾绞痛的疗效及安全性。方法:患者100例,随机分为2组,每组50例。实验组给予生理盐水100ml+间苯三酚80mg静脉滴注+吗啡9mg静脉分3次推注,对照组给予生理盐水100ml+山莨菪碱10mg静脉滴注+肌注哌替啶50mg。于注射后40min、6h2个时间段观察解痉镇痛效果及其不良反应。结果:治疗40min后,实验组和对照组的显效率分别为46%和38%,两组比较差异无统计学意义(P>0.05)。实验组总有效率和6h内疼痛再发率分别为94%、16%,对照组为80%、34%,两组比较差异有统计学意义(P<0.05);实验组、对照组的不良反应发生率分别为18%、68%,两组比较差异有统计学意义(P<0.01)。结论:吗啡分次注射联合间苯三酚用治疗肾绞痛疗效好,不良反应少,值得临床推广应用。Objective：To evaluate the efficacy and the safety of multiple injection of morphine combined with phloroglucin in the treatment of renal colic.Method：One hundred patients with severe renal colic were randomly divided into two groups.The experiment group was administrated with NS 100 ml ＋ phloroglucinol 80 mg intravenous drop infusion ＋ morphine 9 mg fractionated intravenous injection for three times.The control group was administrated with NS 100 ml＋ anisodamine 10 mg intravenous drop infusion＋ pethidine 50 mg intra muscular injection.The efficacy and the side effect were analyzed and compared between the two groups after administration for 40 min and 6 hours.Result：After 40 min treatment,the efficacy rate between the experiment group and the control group was not significant（46% vs 38%）.The total efficacy of the experiment group was higher than the control group（94% vs 80%）,and the pain recurrence rate in 6 hours of the experiment group was lower than the control group（16% vs 34%）.The incidence of adverse effect of the experiment group was lower than the control group（18% vs 68%）.Conclusion：Multiple injection of morphine combined with phloroglucin is safe and effective in the treatment of renal colic.

关 键 词：吗啡 间苯三酚 肾绞痛 

分 类 号：R692[医药卫生—泌尿科学]