泌尿系统感染病原菌分布及耐药性分析  

Distribution of pathogenic bacteria and analysis of drug resistance in urinary tract infections

作　　者：邹桂玲[1] 杜雪飞[1] 孙哲[1] 孟晓玉[1] 陈国玉[1] 

机构地区：[1]哈尔滨医科大学附属第四医院检验科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2011年第3期275-277,共3页Journal of Harbin Medical University

摘　　要：目的了解本院2001～2008年泌尿系统感染病原菌分类及耐药性的变化,指导临床更合理的应用抗生素。方法收集2001～2008年诊断为泌尿系统感染的病原菌及其体外药敏试验的结果进行分析,室内质控菌株选用ATCC25922、ATCC25923、ATCC27853。结果 2001～2004年与2005～2008年尿培养阳性率及各种病原菌的比率无差异,大肠埃希菌、肠球菌属、真菌、肠杆菌属、葡萄菌属等为主要分离菌,其中大肠埃希菌占首位,肠球菌次之。2001～2004年与2005～2008年病原菌中革兰氏阴性杆菌属比率无差别,但革兰氏阳性球菌属比率有明显差别,并且2005～2008年尿培养分离出的病原菌耐药率明显增加,喹诺酮类抗生素已不再是治疗泌尿系感染的首选药物。结论病原菌对抗生素耐药性不断变化,临床医生应根据药敏结果选择抗生素。Objective To understand the changes of urinary tract infection pathogens in classification and drug resistance and to guide more rational use of antibiotics in clinic.Methods Pathogenic bacteria from patients diagnosed urinary tract infection and their susceptibility test results in vitro from 2001 to 2008 were collected and analyzed,ATCC25922,ATCC25923,ATCC27853 were selected as internal quality control strains.Results The positive rate of urine culture and ratios of various of pathogenic bacteria had no difference between from 2001 to 2004 and from 2005 to 2008.Escherichia coli,Enterococcus,Fungi,Enterobacter spp were the main grape isolated,Escherichia coli bacteria accounted for the most part,followed by enterococci.Gram-negative genus Bacillus had no difference in rates in various of pathogenic bacteria,but gram-positive cocci was significantly different between from 2001 to 2004 and from 2005 to 2008.From 2005 to 2008,the drug resistance rates in pathogen isolated from urine culture was significantly increased and quinolones was no longer the first choice for treatment of urinary tract infection.Conclusion With increasing in resistance to antibiotics of pathogens, clinicians should use antibiotics according to susceptibility test results.

关 键 词：泌尿系统感染 病原菌 耐药性 

分 类 号：R691.3[医药卫生—泌尿科学]