血半胱氨酸蛋白酶抑制剂C在筛查早期肾功能异常中的临床意义  

Clinical value of serum Cystatin C on screening early stage of renal dysfunction of healthy volunteers

作　　者：石莉[1] 孙富强[2] 刘雷[1] 张宜明[1] 李新建[1] 贺凤义[3] 

机构地区：[1]山东省济宁医学院附属医院肾内科,272029 [2]山东省济宁医学院附属医院消化内科,272029 [3]山东省济宁医学院附属医院健康体检中心,272029

出　　处：《临床肾脏病杂志》2011年第6期270-271,共2页Journal Of Clinical Nephrology

摘　　要：目的探讨血半胱氨酸蛋白酶抑制剂C在健康体检中筛查早期肾功能异常的临床意义。方法选择在我院健康体检中心的体检者75名，根据半胱氨酸蛋白酶抑制剂C水平将研究对象分为实验组和对照组，比较2组血半胱氨酸蛋白酶抑制剂C、血肌酐、尿素氮和99mTc—DTPA清除率。结果实验组血清半胱氨酸蛋白酶抑制剂C浓度高于对照组（P〈0．01），实验组肾小球滤过率低于对照组（P〈0．01）。2组血肌酐和尿素氮均在正常范围，组间无统计学差异（P〉0．05）。血清半胱氨酸蛋白酶抑制剂C浓度与肾小球滤过率呈负相关（r=-0．75，P〈0．01）。结论血半胱氨酸蛋白酶抑制剂C是反映肾小球滤过率灵敏指标，为在健康体检中筛查早期肾功能异常提供了一个优于其他的指标。Objective To explore the clinical value of serum Cystatin C on screening the early stage of renal dysfunction of healthy volunteers. Methods A total of 75 cases were chosen in medical examination center of our hospital and divided into experimental group and normal control group according to Cystatin C. The serum creatinine, blood urea nitrogen, serum cystatin C, and 99mTc-DTPA clearance rate were compared between the two groups. Results The serum levels of Cystatin C were significantly higher, but the levels of glomerular filtration rate （GFR） were significantly lower in experimental group than in control group （P〈0. 01）. The levels of serum creatinine and blood urea nitrogen were in normal range, and there was no significant difference between the two groups （P〉 0. 05）. There was a negative correlation between serum Cystatin C and GFR （r= - 0. 75, P〈0. 01）. Conclusions Serum Cystatin C is the sensitive indicator for the change in GFR, which provides a sen- sitive index on screening early stage of renal dysfunction of healthy volunteers.

关 键 词：半胱氨酸蛋白酶抑制剂 肾小球滤过率 肾功能 

分 类 号：R726.92[医药卫生—儿科]