细菌的群体性行为与耐药  

Bacterial group behavior and drug resistance

作　　者：王辉[1] 杨崇广[1] 牛辰[1] 

机构地区：[1]复旦大学上海医学院教育部/卫生部医学分子病毒学重点实验室,上海200032

出　　处：《微生物与感染》2011年第2期122-126,共5页Journal of Microbes and Infections

基　　金：上海市卫生局青年科研项目(2009Y001)

摘　　要：随着抗生素的广泛使用,细菌耐药已经成为一个严重的问题。细菌耐药是一个复杂的过程,涉及宿主、细菌与环境等几个既相互独立又相互作用的因素。很久以来,人们认为细菌以个体为单位进行各种活动,直到发现细菌相互之间也存在联系,才意识到细菌群体对其个体生存的重要性。目前将细菌作为一个群体来研究其耐药行为与机制的研究越来越多,特别是细菌生物膜与细菌程序性死亡两方面受到极大重视。本文综述了细菌生物膜、细菌程序性死亡与耐药相关机制的研究进展。With the increasing usage of antibiotics,bacterial drug resistance has become a serious problem.Bacterial drug resistance is a complex process,involving the host,bacteria and environment,which are independent and interactive factors.For a long time,scientists considered that bacteria behave as individual.Till recently,people found that bacteria communicate with each other.We begin to realize the importance of bacterial group behavior in survival.An increasing number of studies have tended to take bacteria as a group to study the behavior of drug resistance.Now,two important aspects of bacterial group behavior,the biofilm and bacterial programmed cell death draw a lot of attention.In this paper,the research associated with drug resistance mechanisms of biofilms and bacterial programmed cell death is reviewed.

关 键 词：细菌 耐药 生物膜 程序性死亡 

分 类 号：R378[医药卫生—病原生物学]