二神汤中补骨脂素、异补骨脂素的药动学研究  

Pharmacokinetic study on psoralen and isopsoralen in "Ershen Decoction"

作　　者：唐昌娟[1] 施贝[1] 修彦凤[1] 陈德兴[1] 

机构地区：[1]上海中医药大学中药学院,上海201203

出　　处：《上海中医药杂志》2011年第7期72-74,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市教委预算内资助项目(2010JW14);上海市教委方剂学重点学科建设资助项目(Z09011)

摘　　要：目的研究大鼠灌胃二神汤后补骨脂素、异补骨脂素在体内的药动学特征。方法 SD大鼠一次性灌胃给予二神汤,采用HPLC法测定不同时间间隔血药浓度,应用DAS 2.0软件模拟房室模型并计算药动学参数。结果给药后补骨脂素及异补骨脂素在大鼠体内的药时过程符合二室模型,主要药动学参数分别为t1/2=(9.22±2.44)h,(11.40±6.60)h;Tm ax=(9.33±2.73)h,(9.33±2.73)h;Cm ax=(7.91±1.34)mg/L,(3.89±0.54)mg/L;AUC(0-t)=(130.92±18.72)mg.L-1.h-1,(69.49±9.05)mg.L-1.h-1;AUC(0-∞)=(147.81±25.59)mg.L-1.h-1,(83.50±19.83)mg.L-1.h-1;MRT(0-t)=(13.39±1.95)h,(13.75±2.01)h;MRT(0-∞)=(16.97±2.87)h,(19.59±7.49)h。结论二神汤灌胃给药后,补骨脂素、异补骨脂素在大鼠血中的吸收、分布和消除皆较慢。Objective To study the pharmacokinetic features of in vivo psoralen and angelicin of ＂Ershen Decoction＂ in rats.Methods SD rats were given by gavage ＂Ershen Decoction＂;HPLC method was used to detect the concentrations of psoralen and isopsoralen at different times,and DAS 2.0 software was applied to simulate atrial and ventricular model and measure the pharmacokinetic parameters.Results After administration,the effective period of psoralen and isopsoralen in rats accorded with two-chamber model,including such main pharmacokinetic parameters as t1/2=（9.22±2.44）h,（11.40±6.60）h;Tmax=（9.33±2.73）h,（9.33±2.73）h;Cmax=（7.91±1.34）mg/L,（3.89±0.54）mg/L;AUC（0-t）=（130.92±18.72）mg·L^-1·h^-1,（69.49±9.05）mg·L^-1·h^-1;AUC（0-∞）=（147.81±25.59）mg·L^-1·h^-1,（83.50±19.83）mg·L^-1·h^-1;MRT（0-t）=（13.39±1.95）h,（13.75±2.01）h;MRT（0-∞）=（16.97±2.87）h,（19.59±7.49）h.Conclusion After administration of ＂Ershen Decoction＂,the absorption and elimination of psoralen and isopsoralen are slow.

关 键 词：二神汤 HPLC 补骨脂素 异补骨脂素 药动学 

分 类 号：R285.5[医药卫生—中药学]