铱催化体系不对称合成手性药物中间体(S)-(-)-1-苯基-1-丙醇  

Asymmetric Synthesis of Chiral Drug Intermediate(S)-(-)-1-Phenyl-1-propanol by Iridium Catalytic System

作　　者：陈毛[1,2] 孙果宋 韦志明 陈小鹏[1] 

机构地区：[1]广西大学化学化工学院,广西南宁530004 [2]广西化工研究院,广西南宁530001

出　　处：《精细化工》2011年第7期723-725,共3页Fine Chemicals

基　　金：广西应用基础研究专项资助项目(桂科基0991016)~~

摘　　要：考察了苯丙酮在手性胺膦配体与[IrHCl2(COD)]2组成的催化体系下不对称转移氢化合成(S)-(-)-1-苯基-1-丙醇的反应,通过正交实验考察了反应温度、n(底物)∶n(铱催化剂)、n(铱催化剂)∶n(手性配体)和碱用量对反应的影响。结果表明,在异丙醇中,利用该体系催化苯丙酮反应6 h后,反应转化率可达94.5%,对映选择性(ee)达96.0%。The iridium catalytic system composed of the [IrHCl2（COD）]2 and the chiral diaminodiphosphine ligand was applied in the asymmetric transfer hydrogenation of propiophenone in the synthesis of（S）-（-）-1-phenyl-1-propanol.The influence of temperature,substrate/catalyst molar ratio,metal complex/chiral ligand molar ratio and lye concentration on the reaction was tested.The results show that 94.5% of conversion rate and 96.0% ee were achieved when propiophenone was reduced for 6 h in this catalytic system.

关 键 词：铱催化体系 不对称转移氢化 (S)-(-)-1-苯基-1-丙醇 苯丙酮 精细化工中间体 

分 类 号：TQ243.4[化学工程—有机化工]