胃肠型GVHD患者不同营养方案的临床疗效  

Clinical effect of different nutrition supporting schemes on gastrointestinal graft-versus-host disease

作　　者：李云龙[1] 张曦[1] 高蕾[1] 刘耀[1] 高力[1] 张诚[1] 刘焕凤[1] 刘学[1] 陈幸华[1] 

机构地区：[1]第三军医大学新桥医院血液科/重庆市医学重点学科,重庆400037

出　　处：《国际检验医学杂志》2011年第11期1163-1164,共2页International Journal of Laboratory Medicine

摘　　要：目的比较不同营养支持方案对胃肠道移植物抗宿主病(GVHD)患者营养状况改善的作用,并对不同营养方案进行评价,观察不同营养方案对胃肠道GVHD辅助治疗的疗效。方法对35例胃肠道GVHD患者随机分为完全肠外营养组(TPN)和经口饮食组(OD),分别于治疗后的0、14、28 d评价患者的营养状况和GVHD临床疗效。结果 35例胃肠道GVHD患者在治疗后14、28 d均为负氮平衡。患者的GVHD临床症状缓解率显示,TPN组大于OD组,P<0.05。结论胃肠道GVHD患者属于营养不良状况,并且随着疾病时间的延长,营养不良状况加重,加重的程度TPN组最慢。TPN有助于抗胃肠道GVHD治疗。Objective To compare the effect of two nutrition supporting schemes for the improvement of the nutrition situation and the therapy of patients with gastrointestinal graft-versus-hbst disease（GVHD）. Methods 35 cases of patients with gastrointestinal GVHD were randomly divided into total praenteral nutrition（TPN） group and oral diet（OD） group. The nutrition situation and therapeutic effect of the two groups were evaluated before therapy,and on the 14th and 28th day after therapy. Results Nitrogen balance was negative in all subjects on the 14th and 28th day. The remission rate of TPN group was higher than that of OD group（P〈0.05）. Conclusion The nutritional situation of patients with gastrointestinal GVHD are poor,and might get worse with the extension of the course of disease. The aggravating speed of nutritional situation in patients with gastrointestinal GVHD accepting TPN scheme might be slow,indicating that TPN scheme could be beneficial to patients with gastrointestinal GVHD.

关 键 词：胃肠道 移植物抗宿主病 完全肠外营养 经口饮食 氮平衡 

分 类 号：R457[医药卫生—治疗学]