载纳米银凹凸棒细胞毒性研究  

Investigation of the cytotoxicity of nanopalygorskite carrying argentum

作　　者：王临艳[1] 王建荣[2] 刘斌[3] 

机构地区：[1]甘肃省妇幼保健院检验科,兰州730050 [2]甘肃省妇幼保健院口腔科,兰州730050 [3]兰州大学口腔医学院修复科,730000

出　　处：《国际检验医学杂志》2011年第11期1179-1180,共2页International Journal of Laboratory Medicine

基　　金：甘肃省兰州市科技资助项目(2009-161)

摘　　要：目的 研究载纳米银凹凸棒的细胞毒性.方法 采用原位还原的方法制备了载纳米银凹凸棒.利用X射线衍射仪（XRD）、X射线光电能谱（XPS）和透射电子显微镜（TEM）分析了载纳米银凹凸棒晶体结构及性能.结果 XRD发现载纳米银凹凸棒中,凹凸棒晶面间距没有变化,同时有银的衍射峰出现;XPS显示,银以单质和离子两种形式存在;TEM对样品形貌的观察表明,粒径为8～11 nm纳米银颗粒较为均匀地负载到凹凸棒表面.细胞毒性实验表明,载纳米银凹凸棒具有较低的细胞毒性.结论 载纳米银凹凸棒细胞毒性低,细胞相容性较高.Objective To investigate cytotoxicity of nanopalygorskite carrying argentum. Methods Nanopalygorskite carrying argentum was prepared by in situ reducing and the structure and performance of it were analyzed by X-ray diffractometer（XRD）, X- ray photoelectron spectroscopy（XPS） and transmission electron microscope（TEM）. Results No change of interplanar spacing,but the diffraction peak of argentum of nanopalygorskite carrying argentum was observed by XRD. The existence of elementary substance and ion type of argentums was confirmed by XPS. The argentum particles,with diameters about 8-11 nm,were equally load- ed to the surface of nanopalygorskite carrying argentums,indicated by TEM. The cytotoxicity of nanopalygorskite carrying argenturns was weak, confirmed by cytotoxicity assay. Conclusion Nanopalygorskite carrying argentum can have low cytotoxicity and high compatibility with cells.

关 键 词：凹凸棒 银 细胞毒性 免疫 

分 类 号：R114[医药卫生—卫生毒理学]