颅脑损伤患者应用依达拉奉的临床效果观察  

Effect of Edaravone in patients with craniocerebral injury

作　　者：黄云华[1] 苟锡军[2] 张兴德[1] 

机构地区：[1]成都市新都区人民医院神经外科,四川成都610500 [2]成都市新都区人民医院ICU,四川成都610500

出　　处：《实用医院临床杂志》2011年第4期125-127,共3页Practical Journal of Clinical Medicine

摘　　要：目的观察颅脑损伤患者应用依达拉奉的临床效果。方法将90例颅脑损伤患者分为治疗组和对照组各45例,对照组给予常规治疗,治疗组在常规治疗基础上加用依达拉奉。比较两组患者出院时格拉斯哥预后评分(GOS)、脑水肿缓解程度。结果出院时治疗组脑水肿改善率高于对照组,GOS评分疗效也优于对照组,差异均有统计学意义(P<0.05)。结论依达拉奉对常规治疗颅脑损伤有较好的增效作用,且临床应用安全。Objective To investigated the protective effect of Edaravone on brain edema in patients with craniocerebral injury.Methods These acute craniocerebral injury patients were randomly divided into two groups,of which 45 cases were given routine therapy,and assigned to control group.The other 45 cases,besides the routine therapy,were given Edaravone injection（30 mg added in physiological saline 100 ml,iv gtt,two times per day）,and assigned to Edaravone group.Results GOS score and brain edema after treatment of the two groups were significantly different（P0.05）.Conclusion Edaravone for acute craniocerebral injury patients can lessen brain edema,promote recovery of nerve function and lower morbidity with little adverse reaction and high security.

关 键 词：依达拉奉 颅脑损伤 脑水肿 

分 类 号：R651.15[医药卫生—外科学] R453[医药卫生—临床医学]