高血压伴胰岛素抵抗与动脉粥样硬化相关性研究  

Study on the relationship between artherosclerosis and insulin resistance with hypertension in patients

作　　者：张国成[1] 王继萍[1] 王叶宝[1] 冷吉燕[1] 

机构地区：[1]吉林大学第一医院干部病房,吉林长春130021

出　　处：《中国实验诊断学》2011年第6期1025-1027,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省发展与改革委员会基金资助(2009)

摘　　要：目的探讨高血压伴胰岛素抵抗与颈动脉粥样硬化的相关性。方法选择符合入选标准的高血压患者60例,根据胰岛素抵抗指数≥2.8为胰岛素抵抗诊断标准,将其分为高血压伴胰岛素抵抗组(EH伴IR)27例,高血压无胰岛素抵抗组(EH无IR)33例,另选20例体检健康者为正常对照组。对所有受试者进行一般检查及血糖、血脂等生化检查,运用logic 9彩色超声检查仪器测定颈总动脉内-中膜厚度及血管内径。结果颈总动脉内-中膜厚度(CCA-IMT)和颈总动脉内径在对照组、EH无IR组和EH伴IR组中逐渐增高,且EH伴IR组与EH无IR组比较,EH伴IR组与对照组比较,EH无IR组与对照组比较,差异均有统计学意义(P<0.05)。Objective To investigate the relationship between hypertension,insulin resistance and artherosclerosis.Methods Sixty patients with essential hypertension were recruited.According to the level of homeostasis model assessment（HOMA-IR）,HOMA-IR≥2.8 as the standard of insulin resistance,twenty-seven patients were classified as essential hypertension with insulin resistance（EH with IR）,and thirty-three as essential hypertension without insulin resistance（EH without IR）.Another 20 healthy individuals were selected as the control groups.HOMA-IR was calculated as a measture of insulin resistance.Carotid IMT and inner diameter were measured by logic9 colour ultrasonography.Results Common carotid artery IMT（CCA-IMT） in patients of control groups,EH without IR and EH with IR were increased gradually,and compare each of them there is a statistical significance（P0.05）.

关 键 词：动脉粥样硬化 高血压 胰岛素抵抗 

分 类 号：R544.1[医药卫生—心血管疾病] R543.4[医药卫生—内科学]