深圳市孕中期HCG、AFP、FE3激素水平表达观察及研究  

A study on the maternal serum HCG,AFP,FE3 level in Shenzhen city

作　　者：邹建话[1] 张修发[1] 江凡[1] 罗惠玲[1] 陈睿[1] 李丽华[1] 

机构地区：[1]深圳市宝安区妇幼保健院,广东深圳518133

出　　处：《中国实验诊断学》2011年第6期1044-1045,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨孕中期β绒毛膜促性腺激素(β-HCG)、甲胎蛋白(AFP)、游离雌三醇(FE3)激素表达水平的意义。方法化学发光免疫分析法检测5063例孕周14.0-21+6的妊娠妇女血清β-HCG、AFP、FE3的水平,筛查阳性患者。结果 5 063例孕妇共检出出生缺陷85例,检出率1.68%,假阳性80例,假阳性率1.58%。4978例正常新生儿,其母亲血清β-HCG、AFP、FE3的正常值分别为(1.15±0.88)、(1.22±0.75)、(1.31±0.88)MOM。高危产妇与正常产妇出生缺陷胎儿的检出率无显著性差异(P>0.05)。结论β-HCG、AFP、FE3联合检测是严重胎儿缺陷产前诊断的有效方法。Objective To investigate the significance of β human chorionic gonadotropin（β-HCG）,alpha-fetoprotein（AFP）,free estriol（FE3） expression levels in the second trimester pregnant woman.Methods The serum β-HCG,AFP,FE3 level in 5063 cases of 14.0-21＋6 weeks of gestation in pregnant women was respectively detected by ECIA to screen the positive patients.Results 85 cases having birth defects were detected from 5 063 cases,the detection rate was 1.68%,80 cases was false positive and the false-positive rate was 1.58%.4978 cases having normal newborns,the serum β-HCG,AFP,FE3 normal values was（1.15±0.88）,（1.22±0.75）,（1.31±0.88） MOM respectively.The detection rate had no significant difference between the high-risk and the fetal birth defects lying-in woman（P0.05）.Conclusion It is effective method of prenatal diagnosis combined with β-HCG,AFP and FE3 detection.

关 键 词：绒毛膜促性腺激素 甲胎蛋白 雌三醇 胎儿疾病 产前诊断 

分 类 号：R714.5[医药卫生—妇产科学]