双黄连注射液与利巴韦林等联合用药后对渗透压的影响  

Study on the Change of Osmotic Pressure of Shuanghuanglian Injection after Drug Combination with Ribavirin etc

作　　者：刘利群 庄舒翔 白政忠 金涛[2] 

机构地区：[1]黑龙江省食品药品检验检测所,哈尔滨150001 [2]黑龙江大学,哈尔滨150086

出　　处：《黑龙江医药》2011年第3期375-376,共2页Heilongjiang Medicine journal

摘　　要：目的:考察双黄连注射液与利巴韦林等药物联合用药后渗透压的变化,为临床中西药联合用药的安全性提供依据。方法:根据临床用药说明书,模拟临床联合使用双黄连注射液和利巴韦林及抗生素,测定联合用药前后各溶液渗透压。结果:双黄连注射液及临床联合使用利巴韦林及抗生素前后,等渗溶液(氯化钠注射液0.9%以及葡萄糖注射液5%)的渗透压无显著变化。结论:双黄连注射液及临床联合使用利巴韦林及抗生素前后,对等渗溶液(氯化钠注射液0.9%以及葡萄糖注射液5%)的渗透压无显著影响。渗透压的变化不是造成药物临床不良反应的主要原因。Objective：To inspect the change of osmotic pressure of shuanghuanglian injection after drug combination with ribavirin etc,to supply a according of the safety of drug combination at clinic using.Methods：On the basis of the insert of medicines,simulating clinical medication,to determin the osmotic pressure of shuanghuanglian injection before and after drug combination with ribavirin and antibiotics.Results：Shuanghuanglian injection before and after drug combination with ribavirin and antibiotics,there are no striking change for the osmotic pressure of 5% Glucose and 0.9% Sodium Chloride Injection.Conclusion：Shuanghuanglian injection before and after drug combination with ribavirin and antibiotics,there are no striking effection for the osmotic pressure of 5% Glucose and 0.9% Sodium Chloride Injection.The change of osmotic pressure was not the cause of untoward reaction in clinical.

关 键 词：双黄连注射液 联合用药 渗透压 

分 类 号：R969.3[医药卫生—药理学]