风湿骨痛药酒药槌外治法对兔退变腰椎间盘内磷脂酶A2活性的影响  

The effect of external treatment of medicated mallet of Fengshi Gutong Herb Liquor on phospholipase A2 activity in the degenerative intervertebral disc in rabbit model

作　　者：肖强兵[1] 白书臣[1] 何承建[1] 曾俊华[1] 李浩[1] 陈大伟[1] 

机构地区：[1]湖北中医药大学附属医院,湖北武汉430061

出　　处：《湖北中医学院学报》2011年第3期3-5,共3页Journal of Hubei College of Traditional Chinese Medicine

基　　金：湖北省教育厅重点科研项目（Q20091607）

摘　　要：目的观察风湿骨痛药酒药槌对兔退变椎间盘内磷脂酶A2（PLA2）活性的影响,探讨其防治椎间盘源性下腰痛的机理。方法采用在X光机透视定位下经皮穿刺破坏椎间盘的造模方法,将21只实验兔随机分为3组：风湿骨痛药酒药槌外治法治疗组、药物治疗组和模型对照组。造模8周后开始治疗3,周后手术取L4-5椎间盘进行PLA2活性检测。结果与模型组比较,两治疗组PLA2活性明显降低（P〈0.01）。外治法组与药物治疗组比较,PLA2活性无明显差异（P〉0.05）。结论风湿骨痛药酒药槌外治法可降低椎间盘内PLA2活性,这可能是其防治椎间盘源性下腰痛的机制之一。Objective To study the effect of external treatment of medicated mallet of Fengshi Gutong Herb Liquor on phospholipase A2 activity in the degenerative intervertebral disc in rabbit model and exploring its mechanism of treatment and prevention on discogenic low back pain.Methods 21 rabbits,after modeled by injuring the intervertebral disc percutaneously under X-ray,were randomly divided into 3 groups： mallet of Fengshi Gutong Herb Liquor group,medicine treatment group,model control group.Treatment was given after 8 weeks after modeling,L4-5 intervertebral disc was sampled for PLA2 activity detection.Results Compared with model control group,PLA2 activity of both treatment groups were significantly lower（P0.01）.No significant difference was observed in comparison between the external treatment group and medicine treatment group（P0.05）.Conclusion Mallet of Gutong Herb Liquor mallet of Gutong Herb Liquor can lower the PLA2 activity in intervetebral disc,which may be a mechanism of treating dicogenic back pain.

关 键 词：腰椎间盘 椎间盘源性下腰痛 风湿骨痛药酒药槌外治法 磷脂酶A2 

分 类 号：R244[医药卫生—针灸推拿学]