红松松塔加压热提取物对S180荷瘤小鼠肿瘤生长及胸腺、脾指数的影响  

Effects of pine cone extract on S180 sarcomas growth,thymus and spleen indices in mouse

作　　者：杨悦[1] 姬宏飞[1] 王波[1] 安巍巍[1] 

机构地区：[1]黑龙江省肿瘤防治研究所,哈尔滨150081

出　　处：《实用肿瘤学杂志》2011年第3期212-214,共3页Practical Oncology Journal

基　　金：黑龙江省科技厅自拟课题资助项目（2009-01）;黑龙江省科技计划项目（PC09S04）

摘　　要：目的探讨红松松塔加压热提取物（PCE）对S180荷瘤小鼠肿瘤生长及胸腺、脾指数的影响。方法选用腋下接种S180肉瘤的健康小鼠，建立荷瘤小鼠模型，24h后随机分4组，即溶剂对照组、环磷酰胺组和PCE大、小剂量组；另设不接瘤的正常对照组。每日称体重后，按0．02mL/g灌胃给药1次，给药14d后称体重、处死，取瘤块、胸腺、脾脏称湿重，计算抑瘤率、胸腺、脾指数。结果与对照组比较，各给药组小鼠脾指数和胸腺指数均未出现有统计学意义的改变；PCE大剂量组抑瘤率为46．1％。结论红松松塔加压热提取物对S180荷瘤小鼠的肿瘤生长有一定的抑制作用。Objective To investigate the effect of Pine Cone Extract（PCE） on the mice with transplanted S180 sarcoma. Methods On the second day after S180 sarcomas being transplanted into the right axilla of mice, the mice were divided into four groups （water control group, cyclophosphamide group, low PCE group and high PCE group）and administered water,cyelophosphamide（ip） ,low PCE group and high PCE by gavage for 14 days, respectively. The dose volume was 0.02 mL/g body weight and once daily. Another group was used as normal control. Then indices of thymus and spleen and inhibitory rate of S180 tumor were observed. Results The indices of the thymus and spleen in the tumor PCE group had no significant difference compared with water control group. Inhibition rate of S180 sarcoma in the high PCE group compared with the control group was 46.1%. Conclusion PCE obviously inhibits the growth of S180 sarcoma with 14 days administration at suitable dosage.

关 键 词：红松松塔 S180肉瘤 抗肿瘤作用 胸腺指数 脾指数 

分 类 号：R961[医药卫生—药理学] R733.6[医药卫生—药学]