微生态制剂防治先天性巨结肠术后小肠结肠炎的临床研究  

Clinical study on probiotics in the prevention of hirschsprung's enterocolitis after surgery

作　　者：尹艳兵[1] 王忠荣[1] 何晓睿[1] 王亮[1] 

机构地区：[1]安徽医科大学研究生学院附属省立医院,合肥230001

出　　处：《安徽医学》2011年第6期727-729,共3页Anhui Medical Journal

基　　金：武汉同济医科大学同济医院协作科研课题

摘　　要：目的前瞻性研究微生态制剂防治先天性巨结肠术后小肠结肠炎的疗效。方法手术治疗的巨结肠病例随机分组,治疗组按先天性巨结肠术后常规治疗,同时预防性地加用微生态制剂口服3个月;对照组按先天性巨结肠术后常规治疗。在术后6个月内,观察小肠结肠炎的发生率和严重程度。结果治疗组20例出现轻度肠炎1例,发病率为5%;对照组20例出现肠炎3例,发病率为15%。两组差异具有统计学意义(P<0.05)。结论避免巨结肠术后肠炎的发病因素,预防性地应用微生态制剂能降低巨结肠术后肠炎发生机率。Objective To assess the role of probiotics in the prevention of hirschsprung＇s enterocolitis after surgery.Methods Surgical treatment of hirschsprung hospitalized patients was randomly assigned to experimental group or contorl group.Patients in control group were given routine treatment,but probiotics were preventively given to experimental group patients which 3 months after surgery.6 months after surgery,observed and compared the incidence of enterocolitis and severity.Results Patients of experimental group had mild enteritis,and the incidence rate was 5%,while in the control group of 20 patients had 3 cases had enteritis,and the incidence rate was 15%.There was statistically significant difference between two groups（P0.05）.Conclusion Avoiding risk factors of Hirschsprung＇s enterocolitis,preventive application of probiotics can reduce the incidence of Hirschsprung＇s enterocolitis and serverity after surgery.

关 键 词：先天性巨结肠 肠炎 微生态制剂 疗效 

分 类 号：R726.5[医药卫生—儿科]