脂联素受体表达调控的研究进展  

Research Progress in Regulation of Adiponectin Receptors Expression

作　　者：崔晓兵[1] 韩意[1] 李丽[1] 吴立玲[1] 

机构地区：[1]北京大学医学部生理学与病理生理学系,分子心血管学教育部重点实验室,北京100191

出　　处：《生理科学进展》2011年第3期169-174,共6页Progress in Physiological Sciences

基　　金：国家基础科学人才培养基金(NFFTBS)J0630853/J0108;国家自然科学基金(30871014)资助课题

摘　　要：脂联素是主要由脂肪细胞分泌的细胞因子,具有胰岛素增敏、抗炎、抗动脉粥样硬化和保护心肌等作用。脂联素的生物学效应需通过脂联素受体1/2的介导来完成。脂联素受体的表达水平直接影响到脂联素对下游信号通路的激活及生物学效应的发挥。对调节脂联素受体表达的因素进行研究,不但有助于揭示调控脂联素受体表达的分子机制,而且也为防治代谢紊乱和心血管疾病提供新思路。Adiponectin is an adipokine mainly secreted by adipose tissue,which exerts insulin-sensitivity,anti-inflammation,anti-atherosclerosis and cardio-protective effects.These biological effects are mediated by adiponectin receptor 1 and adiponectin receptor 2.Expression levels of adiponectin receptor affect activation of downstream signaling pathway and biological effects.Research about regulation factors of adiponectin receptor expression contributes discovering the molecular mechanism and provides new ideas for the prevention and treatment of the metabolism disorder and cardiovascular diseases.

关 键 词：脂联素 脂联素受体 表达 调控 

分 类 号：Q291[生物学—细胞生物学]