针灸对海洛因复吸大鼠脑组织多巴胺、5-羟色胺的影响  

Effects of Acupuncture and Moxibustion on Levels of Dopamine and 5-Hydroxytryptamine in Brains of Rats with Heroin Relapse

作　　者：蔡兴慧[1] 石芳芝[1] 宋小鸽[2] 侯晓蓉[3] 张荣军[4] 吕航[1] 

机构地区：[1]安徽中医学院针灸骨伤临床学院,安徽合肥230038 [2]安徽中医学院针灸经络研究所,安徽合肥230038 [3]安徽中医学院研究生部,安徽合肥230038 [4]安徽中医学院中西医结合临床学院,安徽合肥230038

出　　处：《安徽中医学院学报》2011年第3期38-41,共4页Journal of Anhui Traditional Chinese Medical College

基　　金：针灸基础与技术安徽省重点实验室培育基地开放基金(2009zjkf005c);安徽省科技攻关项目(07010302205)

摘　　要：目的探讨针灸干预海洛因复吸的作用机制。方法采用间断性递增量肌肉注射海洛因的方法复制海洛因复吸大鼠模型,观察针灸对海洛因复吸大鼠条件性位置偏爱(conditional position preference,CPP)的行为学改变及脑组织多巴胺(dopamine,DA)、5-羟色胺(5-hydroxytryptamine,5-HT)含量变化的影响。结果针灸能防止海洛因复吸大鼠体质量的下降(P<0.01),显著延长海洛因复吸大鼠在暗箱的停留时间(P<0.01),显著降低海洛因复吸大鼠脑组织DA和5-HT含量(P<0.01)。结论抑制脑组织DA、5-HT的释放,降低对海洛因用药行为有关环境的依赖行为,可能是针灸干预海洛因复吸的作用机制之一。Objective To research the mechanism of acupuncture and moxibustion in treating heroin relapse.Methods The rat model of heroin relapse was induced by intramuscular injection of incremental dosageheroin at three 8-day stages by two 5-day breaks.The behavioral changes of conditional position preference,and the levels of dopamine（DA） and 5-hydroxytryptamine（5-HT） in the brains were observed in rats with heroin relapse.Results Acupuncture and moxibustion significantly inhibited the decrement of body mass,statistically decreased the levels of DA and 5-HT in the brains,and significantly prolong the retention time in the dark box in the rats with heroin relapse（P〈0.01）.Conclusion One of the mechanisms of acupuncture and moxibustion in intervening heroin relapse might be related with inhibiting the release of DA and 5-HT in the brain,and decreasing the dependence on circumstances correlated with administering heroin.

关 键 词：海洛因复吸 条件性位置偏爱 多巴胺 5-羟色胺 针灸 

分 类 号：R749.61[医药卫生—神经病学与精神病学] R246[医药卫生—临床医学]