改性介孔分子筛对布洛芬的吸附与控制释放  

Amine-Functionalized Mesoporous Materials as Carriers for Adsorption and Controlled Drug Delivery of Ibuprofen

作　　者：陈雷[1] 张翻[1] 邵新超[1] 梁俊虎[1] 宋丽娟[1] 

机构地区：[1]辽宁石油化工大学辽宁省石油化工重点实验室,辽宁抚顺113001

出　　处：《化学工业与工程》2011年第4期11-15,共5页Chemical Industry and Engineering

基　　金：国家自然基金资助项目(20976007)

摘　　要：采用合成后改性将氨基嫁接进介孔MCM-41和SBA-15孔道内,对功能化的2种分子筛进行药物吸附与控制释放的研究。利用红外光谱仪(IR)、智能重量分析仪(IGA)等表征手段对吸附剂的物理结构和化学组成进行表征。对药物布洛芬(IBU)的吸附量进行比较,结果表明,氨基改性的MCM-41(MCM-41-NH2)对布洛芬的吸附性能大于氨基改性的SBA-15(SBA-15-NH2)。在pH值为2.0时,2种载体中IBU释放的相对最慢,S-NH2-IBU比M-NH2-IBU释放的缓慢;在pH值为4.0时,S-NH2-IBU则比M-NH2-IBU释放的要快;而在pH值为7.4时,2种载体中IBU释放速率相对比较快,S-NH2-IBU比M-NH2-IBU释放的要快。缓释速率的不同可能是源于2种分子筛不同的形态和孔道结构。Mesoporous materials were modified with amine groups after synthesis,the functionalized MCM-41 and SBA-15 were investigated as matrix for adsorption and controlled drug delivery.The structure,composition and framework of the matrix were characterized by infrared spectrometer（IR） and intelligent gravitation analyzer（IGA）.MCM-41-NH2 showed higher loading capacity of IBU than SBA-15-NH2.Releasing experiments showed,IBU released more slowly from two medium at pH=2.0,and released more slowly from S-NH2-IBU than that from M-NH2-IBU,while faster from S-NH2-IBU than that from M-NH2-IBU at pH=4.0.But IBU released relatively faster at pH=7.4,IBU released faster form S-NH2-IBU than that from M-NH2-IBU.Different releasing rates may result from the different morphology and pore structure of the carrier particles.

关 键 词：MCM-41-NH2 SBA-15-NH2 布洛芬 吸附 缓释 

分 类 号：R971.1[医药卫生—药品]