职业性慢性砷中毒周围神经病临床特征分析  

Clinical Features of Peripheral Neuropathy in Patients with Occupational Chronic Arsenic Poisoning

作　　者：赖燕[1] 肖雄斌[1] 李海霞[1] 张晓华[1] 

机构地区：[1]湖南省劳动卫生职业病防治所职业病医院,湖南长沙410007

出　　处：《实用预防医学》2011年第6期992-994,共3页Practical Preventive Medicine

摘　　要：目的探讨职业性慢性砷中毒周围神经病的临床特征,为早期诊断提供科学依据。方法对72例职业性慢性砷中毒伴有周围神经病变的程度与发砷含量之间进行相关回归分析。结果 72例职业性砷中毒病例中,临床表现以乏力、四肢麻木等症状为主;发砷含量与神经传导速度之间呈负相关;与神经末端潜伏期呈正相关;不同发砷组别中发砷值越高,外周神经损害程度越明显。结论职业性慢性砷中毒周围神经病,以神经传导速度减慢和潜伏期延长为主要改变,损害程度与发砷含量有明显相关,提示砷在体内的蓄积程度与周围神经损害呈明显关联。Objective To explore the clinical characteristics of peripheral neuropathy in patients with occupational chronic arsenic poisoning,and to provide the scientific evidence for the early diagnosis.Methods The associativity between peripheral neuropathy and arsenic level in hair was evaluated in 72 patients with occupational chronic arsenic poisoning by correlative statistical analysis.Results The chief symptoms of these patients were acratia and limbs anesthesia.The arsenic level in hair was negatively correlated with nervous conductive velocity（NCV）,but positively correlated with the latent phase of peripheral nerve（LPN）.The higher the arsenic level in hair,the more obvious the lesion of peripheral nerve.Conclusions Slowed NCV and prolonged LPN are the dominant pathological changes for the peripheral neuropathy of occupational chronic arsenic poisoning.There is an obvious relationship between the impaired degree of peripheral neuropathy and the increasing arsenic level in hair.The results suggest that there is an apparent relationship between peripheral neuropathy for chronic exposure to arsenic and accumulated arsenic level in human body.

关 键 词：砷中毒 周围神经病 发砷值 

分 类 号：R135[医药卫生—劳动卫生]