抗氧化剂对妊娠结局的影响  

Influence on Using Antioxidant to Pregnant Outcome

作　　者：杨怡珂[1] 林建华[1] 林其德[1] 张为远[2] 

机构地区：[1]上海交通大学医学院附属仁济医院(东部)妇产科,200127 [2]首都医科大学附属北京妇产医院

出　　处：《国际妇产科学杂志》2011年第3期214-217,共4页Journal of International Obstetrics and Gynecology

基　　金：国家十五科技攻关项目<妊娠高血压疾病与凝血相关并发症的防治研究>(2004BA720A06-01)

摘　　要：目的:妊娠期妇女预防性应用抗氧化剂(维生素C,维生素E和丹参),了解抗氧化剂对产科并发症、分娩情况和围生儿情况的影响。方法:将2005年4月—2006年7月全国24家医院3 485例妊娠妇女前瞻性随机分为抗氧化剂组[应用维生素和(或)丹参者,1 607例]与对照组(未用任何药物者,1 878例),序贯性监测其产科并发症、分娩情况及新生儿情况。结果:①2组产科并发症比较,抗氧化剂组胎膜异常、胎儿宫内窘迫和羊水异常的发生率均低于对照组(P<0.01),但2组间妊娠期糖尿病(GDM)、妊娠期高血压(PIH)和妊娠合并肝内胆汁淤积(ICP)发生率的差异无统计学意义(P>0.05)。②抗氧化剂组平均妊娠周为39.17周,平均新生儿体质量为3 388.29 g,对照组平均分娩时间为39.08周,新生儿体质量为3 374.81 g,2组间差异均无统计学意义(P>0.05)。2组间早产、低体质量儿及巨大儿的发生率差异均无统计学意义(P>0.05)。③抗氧化剂组孕产妇病死率为0,围生儿病死率为0.44%,对照组分别为0.11%和0.11%,2组间差异无统计学意义(P>0.05)。④抗氧化剂组的新生儿疾病发病率明显低于对照组(P<0.01),以新生儿黄疸最为显著。结论:妊娠期应用抗氧化剂对分娩时间、新生儿体质量、早产、低体质量儿、巨大儿、孕产妇及围生儿病死率等无明显影响,而对预防部分产科并发症和新生儿疾病等方面有所帮助,尤其预防胎膜早破、新生儿黄疸等疾病的效果肯定。Objective：To apply the antioxidants（Vitamin C,Vitamin E,Salvia Miltiorrhiza L：SML） preventively to the pregnant women,to investigate the influence of using the antioxidants to the obstetrical complications,the conditions of delivery and perinatal.Methods：From April 2005 to July 2006,3 485 pregnant women from 24 national wide cooperative hospitals were involved in this prospective research project.The participants were randomly divided into two groups：1 607 cases included in antioxidant group with administration of vitamins and SML;1 878 cases were in control group without any medicine given.Every participant was under monitoring for the pregnant complications,the delivery condition and perinatal condition.Results：①The incidence of membrane disorders,the fetal distress and amniotic fluid abnormalities in antioxidant group were lower than that in control group（P 0.01）.Nevertheless,there was no difference between two groups in the morbidity of GDM,PIH and ICP（P 0.05）.②The average delivery week of antioxidant group and control group were 39.17w vs.39.08w（P 0.05）,and the average newborn weight of two group were 3 388.29 g vs.3 374.81 g（P 0.05）.There was no difference in the incidence of premature labor,low-birth weight and giant babies between two groups（P 0.05）.③The maternal mortality of anti-oxidant group and control group were 0 vs.0.11%（P 0.05）,and the perinatal mortality of two groups were 0.44% vs.0.11%（P 0.05）.④The newborn morbidity in antioxidant group were lower than control group（P 0.01）,especially in newborn jaundice.Conclusions：There were no influence to the delivery weeks,the newborn weight,premature labor,low-birth weight of newborn,giant babies,the maternal and perenatal motality with using the antioxidants.Whereas,the antioxidants could give some help for preventing some obstetrical complications and newborn diseases,especially in the preventing PROM and newborn jaundice which effects were confirmed.

关 键 词：抗氧化剂 妊娠结局 分娩并发症 高血压 妊娠性 糖尿病 妊娠 

分 类 号：R714.7[医药卫生—妇产科学]