益气化痰祛瘀方对冠心病大鼠6-酮前列腺素F_(1α)和血栓素B_2的影响  

Effect of Yiqi Huatan Quyu Fang on 6-Keto-PGF_(1α) and TXB_2 in Rats with Coronary Heart Disease

作　　者：赵淑明[1] 张文立[2] 吴中秋[1] 张一昕[1] 李昌[1] 高玮[1] 田义龙[1] 

机构地区：[1]河北医科大学,石家庄050091 [2]河北医科大学第二医院

出　　处：《河北中医药学报》2011年第2期7-7,16,共2页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省科技厅科技支撑计划项目:No08276101D-37

摘　　要：目的:观察益气化痰祛瘀方对冠心病大鼠血浆6-酮前列腺素F1α(6-Keto-PGF1α)和血栓素B2(TXB2)的影响,以探讨其治疗冠心病的作用机制。方法:采用喂饲高脂饲料和腹腔注射脑垂体后叶素的方法复制冠心病大鼠模型,实验分组为正常组、模型组、复方丹参滴丸对照组、益气化痰祛瘀方高、低剂量组,施加相应药物干预后,测定各组大鼠血浆6-Keto-PGF1α和TXB2含量。结果:模型组大鼠6-Keto-PGF1α含量明显降低(P<0.01),TXB2含量明显升高(P<0.01);与模型组比较,各用药组大鼠6-Keto-PGF1α含量明显升高(P<0.05或P<0.01),TXB2含量明显降低(P<0.01);高、低剂量组在升高6-Keto-PGF1α和降低TXB2含量方面均优于对照组(P<0.05或P<0.01)。结论:益气化痰祛瘀方可能通过升高6-Keto-PGF1α含量、降低TXB2含量,调节6-Keto-PGF1α与TXB2的平衡状态,恢复血管内皮的正常结构及功能,以达到治疗冠心病的目的。Objective: to observe the effect of Yiqi Huatan Quyu Fang(YHQF) on the 6-Keto-PGF1α and TXB2 in rats with coronary heart disease so to explore its therapeutic mechanism.Methods: rat models with coronary heart disease,made with high fat diet and intraperitoneal injection of pituitrin,were divided into normal group,model group,compound Danshen dripping pill(DSDP) group,YHQ high and low dose groups.6 weeks after the corresponding drug intervention,6-Keto-PGF1α and TXB2 contents were detected.Results: 6-Keto-PGF1α decreased significantly(P<0.01) and TXB2 increased(P<0.01);compared to model group,6-Keto-PGF1α increased significantly(P<0.05 or P<0.01) and TXB2 decreased(P<0.01);both dose groups were superior to control group(P<0.05 or P<0.01).Conclusion: YHQF can treat coronary heart disease by increasing 6-Keto-PGF1α,decreasing TXB2 content and regulating the balance between 6-Keto-PGF1α,and TXB2 to restore the normal structure and function of vascular endothelial.

关 键 词：益气化痰祛瘀方 冠心病 6-酮-前列腺素F1Α 血栓素B2 复方丹参滴丸 

分 类 号：R285.5[医药卫生—中药学]