聚乙二醇支持的CuI催化Huisgen环加成反应合成三氮唑(英文)  

Synthesis of Triazoles by PEG Supported CuI Catalyzed Huisgen Cycloaddition Reaction

作　　者：郑彩云 胡劲松[2] 余述燕[2] 商永嘉[2] 

机构地区：[1]广州番禹职业技术学院,广东广州511483 [2]安徽师范大学化学与材料科学学院,安徽芜湖241000

出　　处：《安徽师范大学学报（自然科学版）》2011年第3期244-249,共6页Journal of Anhui Normal University(Natural Science)

基　　金：Supported by National Natural Science Foundation of China(20872001);the Natural Science Foundation of Education Administration of Anhui Province(KJ2008A064)

摘　　要：我们发展了聚乙二醇(PEG4000)支持的CuI催化的Huisgen环加成反应合成三氮唑衍生物的新颖方法.在聚乙二醇(PEG4000)支持的CuI的催化下,芳基叠氮和末端炔的Huisgen环加成反应以较高的收率得到三氮唑衍生物.初步研究负载催化剂的回收使用情况.An efficient synthetic method for aromatic triazoles accelerated by rpolymer-supported CuI as catalyst between organic azides and terminal alkynes has developed.Treatment of terminal alkynes with benzyl azide or aryl azides in water smoothly gave the Huisgen 1,3-dipolar cycloaddition products,triazoles.The novel Cu（I） complex has shown good activity and stability after eight catalytic cycles.

关 键 词：1 3-偶极环加成反应 三氮唑 聚乙二醇支持的CuI 

分 类 号：O621.3[理学—有机化学]