全身炎症反应综合征患儿血管内皮细胞损伤标志物sTM、sEPCR、vWF表达的变化  

Changes of Endothelial Cell injury Indicators sTM, sEPCR and vWF in Children with Systemic Inflammatory Response Syndrome

作　　者：邱剑辉[1] 

机构地区：[1]湖南省浏阳市人民医院儿科,湖南浏阳410300

出　　处：《医学临床研究》2011年第5期919-921,共3页Journal of Clinical Research

摘　　要：【目的】探讨全身炎症反应综合征（SIRS）患儿血浆血管内皮细胞损伤标志物表达的变化。【方法】本院儿科收治的58例SIRS病例为观察组，本院保健门诊体检的健康儿童20例为对照组，检测两组对象血浆可溶性血栓调节蛋白（sTM）、可溶性血管内皮细胞蛋白C受体（sEPCR）和血管性血友病因子（vWF）的水平及治疗前后变化。【结果】与健康对照组相比，SIRS患者血浆sEPCR、sTM、vWF水平明显增高，差异具有统计学意义（P〈O．05）；与治疗前相比，SIRS患者病情好转后血浆sEPCR、sTM、vWF水平明显降低，差异具有统计学意义（P〈O．05）。【结论】血管内皮细胞损伤在SIRS发生发展中可能起重要作用。[Objective] To explore the changes of plasma indicators of endothelial cell injury in children with systemic inflammatory response syndrome（SIRS）. [Methods] Fifty-eight SIRS children in our hospital were enrolled as observation group, and 20 healthy children in health care department were selected as control. The soluble thrombomodulin（sTM）, soluble endothelial protein C receptor（sEPCR） and yon Willebrand factor （vWF） in plasma were detected in all the subjects of two groups. [Results]Compared with healthy controls, plasma sEPCR, sTM and vWF in SIRS patients increased obviously, and there was significant difference（ P 〈0.05）. Compared with before treatment, plasma sEPCR, sTM and vWF in SIRS patients decreased obviously after treatment, and there was also significant difference（ P 〈0.05）. [Conclusion]The vascular endothelial cell injury may play an important role in the genesis and development of SIRS.

关 键 词：脓毒症综合征 受体 细胞表面 yon WILLEBRAND因子 

分 类 号：R725.153[医药卫生—儿科]