痹祺胶囊对实验性骨关节炎大鼠NO、HYP的影响  

Effects of Biqi capsule on NO and HYP levels in rats with Osteoarthritis

作　　者：许放[1] 师咏梅[1] 柳占彪[1] 钟文婕[1] 

机构地区：[1]天津中医药大学中医药研究院,天津300193

出　　处：《天津中医药》2011年第3期237-239,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家科技支撑计划项目(2007BAI47B04)

摘　　要：[目的]观察痹祺胶囊对实验性大鼠膝骨关节炎(OA)一氧化氮(NO)、羟脯氨酸(HYP)的影响。[方法]选Wistar大鼠,木瓜蛋白酶膝关节注射造模,痹祺胶囊灌胃治疗8周,测定血清NO、HYP和尿HYP的含量。[结果]模型组造模后第1天尿HYP明显升高[(17.07±4.10)mg/L],第15天[(9.92±3.09)mg/L]和第64天[(13.77±1.32)mg/L]与正常组无明显差异。模型组大鼠血清NO含量明显升高(22.64μmol/L);痹祺胶囊高、中治疗组能明显降低大鼠血清NO含量(18.24μmol/L和19.14μmol/L)。[结论]痹祺胶囊具有降低OA大鼠血清NO的含量,减轻由NO介导的对关节软骨的损伤作用。[Objective] To observe the effect of Biqi capsule on the Nitric oxide（NO） and hydroxyproline（HYP） in rats with osteoarthritis.[Methods] Wistar rats were used.Papain was injected into their knee joints to establish the animal model of osteoarthritis.They were treated with Biqi capsule through intragastric administration for 8 weeks.The contents of NO and HYP in serum and HYP in urine were detected.[Results] The contents of HYP in urine were obviously increased in model group in the first day [（17.07±4.10） mg/L,P0.05],and were normal in the fifteenth day and sixty-fourth day [（9.92±3.09） mg/L,（13.77±1.32） mg/L,P0.05].The contents of NO in serum were obviously increased（22.64 μmol/L,P0.01） in model group.In treatment group the contents of NO in serum were decreased by Biqi capsule,1.296 g/kg and 0.648 g/kg（18.24 μmol/L and 19.14 μmol/L,P0.01）.[Conclusion] Biqi Capsule can decrease serum contents of NO in OA rats,and ameliorate the NO-mediated damage of the cartilage in joint.

关 键 词：骨关节炎 痹祺胶囊 一氧化氮 羟脯氨酸 

分 类 号：R289.5[医药卫生—方剂学]