正交试验法优选增免强力颗粒制粒工艺研究  

Research on Optimization of Granulation Technology of Zengmian Qiangli Granula through Orthogonal Experimental Design

作　　者：吴宗耀[1] 任非[2,3] 张兰桐[3] 孙莉[2] 倪旭[1] 

机构地区：[1]石家庄市第五医院,河北石家庄050021 [2]河北医科大学第二医院,河北石家庄050000 [3]河北医科大学,河北石家庄050017

出　　处：《中医学报》2011年第6期699-700,共2页Acta Chinese Medicine

基　　金：河北省科技攻关计划项目(编号:05215)

摘　　要：目的:优选增免强力颗粒的最佳制粒工艺。方法:以喷雾制粒后颗粒的含水量为考察指标,采用L9(34)正交法优选流化床喷雾制粒的最佳工艺。结果:流化床喷雾制粒的影响因素程度依次为:A(浸膏相对密度)>B(进风温度)>C(进风量)>D(喷浆速度);最佳流化床喷雾制粒方案为:清浸膏相对密度1.25、进风温度80℃、进风量1 500 m3/h、喷浆速度40 mL/min。结论:确定了增免强力颗粒合理的制粒工艺。Objective：To optimize the best granulation technology of Zengmian Qiangli Granula.Methods：The L9（34）orthogonal experimental design was applied to optimize the fluidized-bed and spray-dried granulation technology with the water content of particles as the observing index after the spray granulation.Results：The sequence of the affecting degrees of the influencing factors was as follows：A（relative density of the extract） B（temperature of air entry） C（quantity of air entry） D（spraying speed）.The optimum scheme of fluidized-bed and spray-dried granulation technology was as follows：relative density of the extract,1.25,temperature of air entry,80 ℃,quantity of air entry,1 500 m3/h and spraying speed,40 mL/min.Conclusion：The reasonable granulation technology of Zengmian Qiangli Granula is determined.

关 键 词：增免强力颗粒 流化床喷雾干燥制粒 正交试验法 

分 类 号：R284.2[医药卫生—中药学]