驻极体对大鼠皮肤显微结构影响的时间效应研究  

A Study of the Time Effect of the Influence of Electret on Rat Skin Structure

作　　者：梁媛媛[1] 董法杰[1] 马琳[1] 崔黎丽[2] 刘鸿越[2] 江键[1] 

机构地区：[1]第二军医大学基础部数理教研室,上海200433 [2]第二军医大学药学院无机教研室,上海200433

出　　处：《广东工业大学学报》2011年第2期88-90,共3页Journal of Guangdong University of Technology

基　　金：国家自然科学基金资助(50977089);军队"十一五"国际合作项目(06H022);上海市自然科学基金资助(10ZR1437600)

摘　　要：利用恒压电晕充电技术制备±1000 V聚丙烯驻极体,通过倒置相差显微镜观察±1000 V聚丙烯驻极体作用大鼠腹部皮肤不同时间后大鼠皮肤显微结构的改变,比较驻极体在不同时间点对皮肤显微结构的影响.结果显示:正负极性驻极体长时间作用于大鼠皮肤后,大鼠皮肤显微结构的变化趋势基本一致,表明驻极体长时间作用均可引起鼠皮角质层不同程度脱落,达到减弱皮肤屏障、促进药物经皮吸收的目的.负极性驻极体对大鼠皮肤的作用与正极性驻极体作用相比有较短的时间延迟效应.The ±1 000 V polypropylene（PP） electrets were prepared by means of the corona charging method.To compare the skin microstructure after the application of electret at different time points,the changes in the skin structure were observed after the application of ±1 000 V PP electrets on rat abdominal skin with the inverted phase contrast microscope.The results indicate that both the positive and negative PP electrets can change the microstructure of rat skin and the changes in the skin structure are basically the same.Therefore,skin stratum corneum can fall off in varying degrees after the application of electret for a long time.Electret can be used in transdermal delivery formulation to reduce the barrier function of skin and increase the drug permeation through skin.Compared with ＋1 000 V PP electret,-1 000 V PP electret has the delaying effect for a shorter time.

关 键 词：驻极体 透皮 皮肤结构 时间窗 

分 类 号：O484.4[理学—固体物理]