大黄酸固体分散体的制备  

Preparation of rhein solid dispersion and their dissolution in vitro

作　　者：韩刚[1] 王传胜[2] 索炜[1] 刘莉[1] 王彦雪[1] 郭肖菲[1] 

机构地区：[1]华北煤炭医学院药学系,河北唐山063000 [2]沈阳化工大学,辽宁沈阳110142

出　　处：《中国医院药学杂志》2011年第13期1090-1093,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:选择不同的载体制备大黄酸固体分散体,以提高大黄酸的溶出度。方法:选用聚乙烯吡咯烷酮(PVP K30)和聚乙二醇(PEG6000)为载体,采用溶剂法制备大黄酸固体分散体;建立测定大黄酸固体分散体体外溶出度的高效液相色谱方法;对固体分散体进行差热分析和红外光谱分析。结果:以聚乙烯吡咯烷酮为载体制备的大黄酸固体分散体能显著增加大黄酸的溶解度和溶出度。制备的大黄酸固体分散体(1∶4),40 min时,大黄酸的累积溶出百分率达85%。物相鉴定表明,大黄酸以无定形状态分散在载体中。结论:以聚乙烯吡咯烷酮为载体制备的大黄酸固体分散体能有效地提高大黄酸的溶出速率。OBJECTIVE To optimize the preparation process of solid dispersions of rhein for improving the drug dissolution. METHODS To prepare rhein solid dispersion by solvent method with polyvinyl pyrrolidone （K30） and polyethylene glycol （PEG）, the determination of dissolution methods was established with HPLC in vitro. RESULTS The rhein solid dispersion could significantly increase the solubility of rhein and its dissolution. Dissolution percentages of solid dispersions were more than 85 percent in the drug carrier ratio of 1：4. The differential scanning calorimetry （DSC） and infrared spectroscopy were used to characterize the rhein solid dispersions. CONCLUSION Solid dispersions could significantly improve solubility and dissolution rate of rhein.

关 键 词：大黄酸 固体分散体 溶出度 聚乙烯吡咯烷酮 聚乙二醇 高效液相色谱法 

分 类 号：R944.2[医药卫生—药剂学]