腺叶香茶菜中具有细胞毒活性的二萜(英文)  

Cytotoxic Diterpenoids from Isodon adenolomus

作　　者：赵伟[1,2] 普建新[1] 杜雪[1] 苏佳[1] 李小年[1] 杨建红[1] 薛永波[1,2] 李艳[1] 孙汉董[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,昆明650204 [2]中国科学院研究生院,北京100049

出　　处：《中国天然药物》2011年第4期253-258,共6页

基　　金：supported by the NSFC-Joint Foundation of Yunnan Province(No.U0832602 to H.-D.Sun);the Major State Basic Research Development Program of China(Nos.2009CB522300 and 2009CB940900);the Science and Technology Program of Yunnan Province(Nos.2008IF010 and 2008CD162);the Major Direction Projection Foundation of CAS Intellectual Innovation Project(No.2010KIBA05 to J.-X.Pu)~~

摘　　要：目的:研究产自云南省香格里拉地区的腺叶香茶菜(Isodon adenolomus)地上部分的化学成分;方法:利用正反相硅胶、高效液相色谱等现代分离技术进行分离;通过IR,UV,MS,NMR等波谱方法鉴定了化合物结构式;对化合物1进行了单晶X-衍射分析,确定了其绝对构型;化合物2-5和10进行了细胞毒活性测定;结果:分离得到7个对映-贝壳杉烷二萜,1个对映-松香烷二萜和两个松香烷二萜;结论:Isoadenolins M-O(1-3)为新化合物,且化合物2-4和10表现出了一定细胞毒活性。AIM：To study the chemical constituents of the aerial parts of Isodon adennolmus collected in the Shangrila region of Yunnan Province,China.METHOD：Compounds 1-10 were separated and purified by silica gel and C18 reversed phase silica gel column chromatography.The structures were elucidated by extensive spectroscopic methods（IR,UV,MS and NMR）,and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis.Compounds 2-5 and 10 were evaluated for their in vitro cytotoxicity against human tumor cell lines,HL-60,SMMC-7721,A-549,MCF-7,and SW-480.RESULTS：One ent-abietane,two abietane,and seven ent-kaurane diterpenoids were isolated and identified.CONCLUSION：Compounds 1-3 are new diterpenoids.Compounds 2-4 and 10 showed moderate inhibitory effects on several of the five tumor cell lines.

关 键 词：化学成分 腺叶香茶菜 二萜 细胞毒活性 

分 类 号：R284.1[医药卫生—中药学]