采用GC-MS及RRLC-Q-TOFMS法分析中药复方附子理中丸的化学成分(英文)  

A Novel Approach to Characterize Chemical Consistency of Traditional Chinese Medicine Fuzi Lizhong Pills by GC-MS and RRLC-Q-TOFMS

作　　者：刘慧[1] 苏娟[1] 杨茜[1] 何雅君[2] 李海云[1] 叶霁[1] 张卫东[1,2] 

机构地区：[1]第二军医大学药学院天然药化教研室,上海200433 [2]上海交通大学药学院,上海200030

出　　处：《中国天然药物》2011年第4期267-273,共7页

基　　金：supported by the program NCET Foundation,NSFC(No.30725045);the Special Program for New Drug Innovation of the Ministry of Science and Technology,China(Nos.2009ZX09311-001,2009ZX09308-005)~~

摘　　要：目的:定性分析中药复方附子理中丸中的化学成分。方法:采用GC-MS和RRLC-Q-TOFMS的方法分别建立附子理中丸的指纹图谱,并对色谱峰进行定性分析。并采用系统聚类分析法对指纹图谱进行分类研究。结果:定性了附子理中丸中的45个成分,依据指纹图谱分析,发现不同厂家的附子理中丸存在一定差异。结论:该方法可以为研究附子理中丸的化学成分和质量标准提供依据。AIM：To identify the chemical compositions of Fuzi Lizhong Pills,a traditional Chinese medicine that has been used for thousands of years in China.METHODS：Fingerprints of different batches of Fuzi Lizhong Pills were developed by gas chromatography-mass spectrometry（GC-MS） and rapid resolution liquid chromatography coupled with photo-diode array detector and time-of-flight mass spectrometry（RRLC-Q-TOFMS）.Based on the fingerprints,the variation of the herbal prescription Fuzi Lizhong Pills was evaluated by hierarchical cluster analysis.RESULTS：We have identified a total of 45 compounds in Fuzi Lizhong Pills with differences among samples from different companies.CONCLUSION：This work provides a method to identify the chemical compositions of Fuzi Lizhong Pills.

关 键 词：GC-MS RRLC-Q-TOFMS 附子理中丸 指纹图谱 

分 类 号：R917[医药卫生—药物分析学]