葡萄糖耐量试验期间对动态血糖监测系统的精确性分析  

Accuracy of a continuous glucose monitoring system in detection of blood glucose during oral glucose tolerance test

作　　者：陈志[1] 沈洁[1] 徐玲玲[1] 符霞军[1] 李际敏[1] 马媛媛[1] 

机构地区：[1]南方医科大学南方医院内分泌代谢科,广东广州510515

出　　处：《南方医科大学学报》2011年第7期1256-1258,共3页Journal of Southern Medical University

基　　金：广东省科技计划项目(2009B011400036)

摘　　要：目的分析葡萄糖耐量试验期间(OGTT)动态血糖值和静脉血糖值的一致性,评价在快速变化的血糖应激状态动态血糖监测系统的精确性。方法对49例空腹血糖3.9～11.0mmol/L的门诊志愿者,应用动态血糖监测系统(CGMS)进行连续3d的血糖监测,并在第3天行OGTT,检测0、30、60、90、120min静脉血糖值,采用Pearson相关分析法、Clarke误差表格分析(EGA)分别评价整个OGTT期间及各血糖状态下CGMS的精确性。结果 CGMS测定值和静脉血糖值在整个OGTT期间、血糖稳定阶段、血糖急升阶段和血糖急降阶段时的r分别为0.928、0.901、0.924和0.902(P值均<0.001),EGA显示均有95%以上的结果落在A区和B区。结论 OGTT期间的CGMS测定值和静脉血糖值相关性良好,EGA结果在可接受范围内,CGMS可较精确性地反映OGTT期间快速血糖变化。Objective To evaluate the accuracy of continuous glucose monitoring system（CGMS） during oral glucose tolerance test（OGTT） in the detection of blood glucose changes in glucose stress condition.Methods Forty-nine out-patients with fasting plasma glucose of 3.9-11.0 mmol/L underwent continuous blood glucose monitoring using CGMS for 3 days,and OGTT was conducted on the third day.The venous blood glucose was measured at 0,30,60,90,and 120 min after oral glucose intake,and the accuracy of CGMS during OGTT was evaluated.Results The correlation indices between CGMS values and the venous blood glucose values during the entire OGTT and in phases of stable,rapidly rising and falling glucose levels were 0.928,0.901,0.924 and 0.902,respectively（P〈0.001）.Clarke error-grid analysis showed that more than 95% of the measured results fell into the A and B zones.Conclusion CGMS values show good consistency with venous blood glucose values measured during OGTT.CGMS is accurate in detection of rapidly changing blood glucose during OGTT.

关 键 词：动态血糖监测 葡萄糖耐量试验 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]