有氧运动对自发性高血压大鼠心肌血红素氧合酶活性及血红素氧合酶-1mRNA表达的影响  

Effects of aerobic exercise on activity of heme oxyenase and expression of heme oxyenase-1 mRNA in cardiac muscle of spontaneous hypertensive rats

作　　者：任彩玲[1] 余志琪[2] 张钧[3] 

机构地区：[1]赣南医学院康复学院,江西赣州341000 [2]兰州城市学院体育系 [3]扬州大学体育学院

出　　处：《中国康复医学杂志》2011年第7期655-658,共4页Chinese Journal of Rehabilitation Medicine

基　　金：赣州市指导性科技计划项目

摘　　要：目的:观察有氧运动对自发性高血压大鼠(SHR)心肌血红素氧合酶(HO)活性及HO-1mRNA表达的影响,探讨适宜的有氧运动对高血压性心肌肥大的防治作用及机制。方法:雄性Wistar大鼠6只为正常对照组(C组),雄性自发性高血压大鼠16只,随机分为高血压组(S组)和高血压运动组(T组)。T组每日进行60min无负重游泳,每周6次,共9周,用RT-PCR方法检测大鼠心脏HO-1mRNA表达。结果:与C组相比,S组心肌HO活性显著降低(P<0.05);与S组相比,T组心肌HO活性显著升高(P<0.05)。与C组相比,各组心肌HO-1mRNA表达差异均有显著性意义,S组心肌HO-1mRNA表达显著升高(P<0.01);与S组相比,T组心肌HO-1mRNA表达也显著升高(P<0.01)。结论:说明长期有规律的运动可以升高SHR心肌HO活性和HO-1mRNA表达。Objective： To investigate the effects of aerobic exercise on activity of heme oxyenase（HO） and expression of HO-1 mRNA in cardiac muscle of spontaneous hypertensive rats（SHR）. Method： Male Wistar rats were assigned as follows： normal control group （C） with： 6normal rats, SHR group （S） with 8 SHRs, training SHR group （T） with 8 SHRs. T group carried on 60min unloaded swimming 6 times a week for 9 weeks. The rats in all groups were fed with normal feedstuff. Nine weeks later activity of HO and expression of HO-1 mRNA were determined by RT-PCR. Result： Activity of HO reduced significantly compared with normal control group （P〈0.05）; the expression of HO-1 mRNA in S group increasd significantly compared with normal control group （P〈0.01）; Compared with S group, activity of HO and expression of HO-1 mRNA in T group increased obviously（P〈0.05, P〈0.01）. Conclusion： The long term regular aerobic exercise can increase activity of HO and expression of HO-1 mRNA obviously and improve the development of cardiac hypertrophy induced by hypertension.

关 键 词：血红素氧合酶 心肌肥大 有氧运动 

分 类 号：R544.1[医药卫生—心血管疾病] R493[医药卫生—内科学]