人工饲养树鼩和猕猴的部分凝血因子凝集时间的测定及分析  

Test and Analysis of Coagulation Time of Four Kinds of Coagulation Factors in Captive Bred Tree Shrew and Rhesus Monkey

作　　者：黄璋琼[1] 代解杰[1] 孙晓梅[1] 李辛斌[2] 高家红[1] 

机构地区：[1]中国医学科学院/北京协和医学院医学生物学研究所,昆明650118 [2]云南中医学院,昆明650500

出　　处：《实验动物科学》2011年第3期37-41,共5页Laboratory Animal Science

基　　金：国家科技支撑计划项目(No:2009BAI83B02);云南省科技基础条件平台建设计划项目(No:2006PT07-2)

摘　　要：目的目前有关人工饲养树鼩与猕猴部分凝血因子凝集时间的资料甚少,拟初步建立这两种动物部分凝血因子凝集时间的参考值范围。方法采用全自动血凝仪测定树鼩、猕猴的血浆凝血酶时间(TT)、纤维蛋白原(Fib)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)。结果树鼩的TT、PT、Fib和APTT值分别为19.27、17.34、30.51和27.88 s。猕猴的TT、PT、Fib和APTT值分别为20.81、9.82、18.73和33.56 s。人工饲养树鼩与猕猴的PT值、Fib值存在显著性差异(P<0.01),APTT值、TT值存在差异(P<0.05)。结论人工饲养树鼩和猕猴部分凝血因子的凝集时间存在一定差异,同一物种雌雄个体间部分凝血因子的凝集时间没有明显差异。Objective To test and analyze the coagulation time of four kinds of coagulation factors in healthy,captive bred tree shrew and rhesus monkey,and to establish the reference values range of coagulation factors values in the two animals.Methods Prothrombin time（PT）,activated partial thromboplastin time（APTT）,fibrinogen time（FIB）,and thrombin time（TT） of captive bred tree shrews and rhesus monkeys were tested by using the Sysmex CA-510 automated blood coagulation analyzer,then the data were analyzed in using the statistics analysis software SPSS v17.0.Results In Tree shrew and Rhesus monkey,TT was respectively 19.27 s and 20.81 s;PT was respectively 17.34 s and 9.82 s;FIB was respectively 30.51 s and 18.73s;APPT was respectively 27.88 s and 33.56 s.The differences in PT and FIB were highly significant（P0.01） between captive bred tree shrew and rhesus monkey;and the differences in TT and APTT were also statistical significant（P0.05） between the captive bred tree shrew and the rhesus monkey.Conclusion There were significant differences in coagulation time of the four kinds of coagulation factors between animals,but there had no differencees in the different gender of same species.

关 键 词：树鼩 猕猴 凝血酶时间 纤维蛋白原 活化部分凝血活酶时间 凝血酶原时间 

分 类 号：Q95-331[生物学—动物学]