复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响  

Influences of Compound Prescription Capsule of Silkworm Powder on Glycometablism and Lipid Metabolism in Type 2 Diabetic Rat

作　　者：曹育[1,2] 黄亦琦[2] 王梅兰[2] 杨辉[2] 樊希承[2] 黄颖[2] 罗友华[2] 

机构地区：[1]福建中医药大学,福州350003 [2]厦门市医药研究所,福建厦门361008

出　　处：《中国实验方剂学杂志》2011年第14期189-191,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：厦门市卫生局科研基金项目(WSK2004Z-1)

摘　　要：目的:观察复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响。方法:采用高脂饲料喂养加小剂量链脲佐菌素(STZ)ip SD大鼠复制实验性2型糖尿病模型,按血糖值将模型大鼠随机分、模型组、复方全蚕粉胶囊低、中、高剂量组(0.5,1.0,2.0 g.kg-1)、阿卡波糖组(3 mg.kg-1),另设正常对照组。给药6周后测定各组大鼠空腹血糖(FPG)、血清胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、血清丙二醛(MDA)、超氧化物歧化酶(SOD),并计算胰岛素抵抗指数(Home-IR)。结果:与模型组比较,复方全蚕粉胶囊各剂量组可使FPG,TC,TG,LDL-C和MDA显著降低,而HDL-C和SOD显著升高(P<0.05或P<0.01),能有效地改善高胰岛素血症状态。结论:复方全蚕粉胶囊能有效调节2型糖尿病大鼠糖、脂代谢紊乱,改善外周组织对胰岛素的敏感性,从而减轻2型糖尿病大鼠的胰岛素抵抗。Objective：To observe the influences of Compound Prescription Capsule of Silkworm Powder（CCSP） on glycometablism and lipid metabolism in type 2 diabetic rat.Method： Male Sprague-Dawley rat model of type 2 diabetes was induced by high-fat diet and low dose streptozotocin（STZ）.Seventy-two model rats were separated according to plasma glucose levels into models,normal control group,model group,low dose group,middle dose group,high dose group and Acarbose tablets group.After 6 weeks,all animals were tested respectively the levels of fasting plasma glucose（FPG） and fasting insulin（FINS）,cholesterol（TC）,triglyceride（TG）,low density lipoprotein-cholesterol（LDL-C）,high density lipoprotein-cholesterol（HDL-C）,malonaldehyde（MDA）,superoxide dismutase（SOD）.Result： Compared with model group.Low,middle and high doses of CCSP could remarkably lower the levels of FPG,FINS,TG,TC,LDL-C and MDA,obviously improve the Home-IR,SOD and HDL-C（P0.05 or P0.01）.It had the amendment of high-insulin.Conclusion： CCSP can effectively adjust the glyco-lipid metabolim,thus to abate insulin resistance.

关 键 词：2型糖尿病 复方全蚕粉胶囊 血糖 血清胰岛素 血脂 大鼠 

分 类 号：R285.5[医药卫生—中药学]